ID   2.1.1.114
DE   polyprenyldihydroxybenzoate methyltransferase.
AN   3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase.
AN   DHHB methyltransferase.
AN   DHHB-Mt.
AN   DHHB O-methyltransferase.
AN   dihydroxyhexaprenylbenzoate methyltransferase.
CA   3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine =
CA   3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-
CA   homocysteine.
CC   -!- This enzyme is involved in ubiquinone biosynthesis.
CC   -!- Ubiquinones from different organisms have a different number of
CC       prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-
CC       9 in rat and ubiquinone-10 in human), and thus the natural substrate
CC       for the enzymes from different organisms has a different number of
CC       prenyl units.
CC   -!- However, the enzyme usually shows a low degree of specificity
CC       regarding the number of prenyl units.
CC   -!- For example, the human COQ3 enzyme can restore biosynthesis of
CC       ubiquinone-6 in coq3 deletion mutants of yeast.
CC   -!- The enzymes from yeast and rat also catalyze the methylation of
CC       3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this
CC       activity is classified as EC 2.1.1.64).
DR   O49354, COQ3_ARATH ;  Q3T131, COQ3_BOVIN ;  O93995, COQ3_CANAX ;
DR   Q54XD0, COQ3_DICDI ;  Q9NZJ6, COQ3_HUMAN ;  Q8BMS4, COQ3_MOUSE ;
DR   Q63159, COQ3_RAT   ;  O74421, COQ3_SCHPO ;  P27680, COQ3_YEAST ;
//