ID   2.1.1.115
DE   (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase.
AN   (RS)-tetrahydrobenzylisoquinoline N-methyltransferase.
AN   norreticuline N-methyltransferase.
CA   (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine =
CA   H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline +
CA   S-adenosyl-L-homocysteine.
CC   -!- Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-
CC       tetrahydroisoquinolines; including coclaurine, norcoclaurine,
CC       isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine.
CC   -!- Both R- and S-enantiomers are methylated.
CC   -!- Participates in the pathway leading to benzylisoquinoline alkaloid
CC       synthesis in plants.
CC   -!- The physiological substrate is likely to be coclaurine.
CC   -!- Was earlier termed norreticuline N-methyltransferase.
CC   -!- However, norreticuline has not been found to occur in nature and that
CC       name does not reflect the broad specificity of the enzyme for (RS)-1-
CC       benzyl-1,2,3,4-tetrahydroisoquinolines.
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