ENZYME entry: EC 2.1.1.148

Accepted Name
Thymidylate synthase (FAD).
Alternative Name(s)
FDTS.
Flavin dependent thymidylate synthase.
Reaction catalysed
5,10-methylenetetrahydrofolate + dUMP + NADPH <=> dTMP + tetrahydrofolate + NADP(+)
Comment(s)
  • Contains FAD.
  • All thymidylate synthases catalyze a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5-position of dUMP and a two electron reduction of the methylene group to a methyl group.
  • Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH.
Cross-references
BRENDA2.1.1.148
EC2PDB2.1.1.148
ExplorEnz2.1.1.148
PRIAM enzyme-specific profiles2.1.1.148
KEGG Ligand Database for Enzyme Nomenclature2.1.1.148
IUBMB Enzyme Nomenclature2.1.1.148
IntEnz2.1.1.148
MEDLINEFind literature relating to 2.1.1.148
MetaCyc2.1.1.148
UniProtKB/Swiss-Prot
P15808, THY1_DICDI;  Q9YA75, THYX_AERPE;  Q5PBM3, THYX_ANAMM;  
O66883, THYX_AQUAE;  O50965, THYX_BORBU;  O64238, THYX_BPMD2;  
Q05259, THYX_BPML5;  Q9ZX92, THYX_BPPHC;  Q9PJ85, THYX_CAMJE;  
Q5HXD2, THYX_CAMJR;  Q8XHQ7, THYX_CLOPE;  Q890M6, THYX_CLOTE;  
C3PH05, THYX_CORA7;  Q6NGP3, THYX_CORDI;  Q8RQM9, THYX_COREF;  
P40111, THYX_CORGL;  Q729U4, THYX_DESVH;  Q5FG35, THYX_EHRRG;  
Q5HAK2, THYX_EHRRW;  Q748A9, THYX_GEOSL;  Q5FR18, THYX_GLUOX;  
Q5V325, THYX_HALMA;  Q9HQ52, THYX_HALSA;  Q9ZJ93, THYX_HELPJ;  
O26061, THYX_HELPY;  C5CHB8, THYX_KOSOT;  A0QIT4, THYX_MYCA1;  
B1MD42, THYX_MYCA9;  P66931, THYX_MYCBO;  A1KM95, THYX_MYCBP;  
C1AFL6, THYX_MYCBT;  A4TCJ4, THYX_MYCGI;  B8ZRR4, THYX_MYCLB;  
Q9CBW3, THYX_MYCLE;  B2HKZ0, THYX_MYCMM;  Q73VZ6, THYX_MYCPA;  
A0QVT0, THYX_MYCS2;  A3PYB1, THYX_MYCSJ;  A1UEV1, THYX_MYCSK;  
Q1BA61, THYX_MYCSS;  A5U6A7, THYX_MYCTA;  P9WG56, THYX_MYCTO;  
P9WG57, THYX_MYCTU;  A1T7Q0, THYX_MYCVP;  O41156, THYX_PBCV1;  
Q9UZ51, THYX_PYRAB;  Q8ZWD6, THYX_PYRAE;  Q8U3C9, THYX_PYRFU;  
O58498, THYX_PYRHO;  Q1RJV8, THYX_RICBR;  Q92IL5, THYX_RICCN;  
Q4UM78, THYX_RICFE;  Q9ZDM6, THYX_RICPR;  Q68X70, THYX_RICTY;  
Q5LTY7, THYX_RUEPO;  Q82K86, THYX_STRAW;  O86840, THYX_STRCO;  
Q4J6F2, THYX_SULAC;  Q980H6, THYX_SULSO;  Q96YF6, THYX_SULTO;  
P73053, THYX_SYNY3;  B7IF44, THYX_THEAB;  Q5JI17, THYX_THEKO;  
A8F7Q7, THYX_THELT;  A6LP90, THYX_THEM4;  Q9WYT0, THYX_THEMA;  
B9KBK3, THYX_THENN;  B6YTN5, THYX_THEON;  A5IJX2, THYX_THEP1;  
B1L944, THYX_THESQ;  Q72JN9, THYX_THET2;  Q5SJB8, THYX_THET8;  
Q73QY2, THYX_TREDE;  O83971, THYX_TREPA;  Q83HF9, THYX_TROW8;  
Q83MS7, THYX_TROWT;  Q73FX5, THYX_WOLPM;  Q7MQK8, THYX_WOLSU;  

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