ID 2.1.1.148 DE thymidylate synthase (FAD). AN FDTS. AN flavin dependent thymidylate synthase. CA (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = CA (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+). CC -!- Contains FAD. CC -!- All thymidylate synthases catalyze a reductive methylation involving CC the transfer of the methylene group of 5,10-methylenetetrahydrofolate CC to the C5-position of dUMP and a two electron reduction of the CC methylene group to a methyl group. CC -!- Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which CC uses folate as both a 1-carbon donor and a source of reducing CC equivalents, this enzyme uses a flavin cofactor as a source of CC reducing equivalents, which are derived from NADPH. DR P15808, THY1_DICDI ; Q9YA75, THYX_AERPE ; Q5PBM3, THYX_ANAMM ; DR O66883, THYX_AQUAE ; O50965, THYX_BORBU ; O64238, THYX_BPMD2 ; DR Q05259, THYX_BPML5 ; Q9ZX92, THYX_BPPHC ; Q9PJ85, THYX_CAMJE ; DR Q5HXD2, THYX_CAMJR ; Q8XHQ7, THYX_CLOPE ; Q890M6, THYX_CLOTE ; DR C3PH05, THYX_CORA7 ; Q6NGP3, THYX_CORDI ; Q8RQM9, THYX_COREF ; DR P40111, THYX_CORGL ; Q729U4, THYX_DESVH ; Q5FG35, THYX_EHRRG ; DR Q5HAK2, THYX_EHRRW ; Q748A9, THYX_GEOSL ; Q5FR18, THYX_GLUOX ; DR Q5V325, THYX_HALMA ; Q9HQ52, THYX_HALSA ; Q9ZJ93, THYX_HELPJ ; DR O26061, THYX_HELPY ; C5CHB8, THYX_KOSOT ; A0QIT4, THYX_MYCA1 ; DR B1MD42, THYX_MYCA9 ; P66931, THYX_MYCBO ; A1KM95, THYX_MYCBP ; DR C1AFL6, THYX_MYCBT ; A4TCJ4, THYX_MYCGI ; B8ZRR4, THYX_MYCLB ; DR Q9CBW3, THYX_MYCLE ; B2HKZ0, THYX_MYCMM ; Q73VZ6, THYX_MYCPA ; DR A0QVT0, THYX_MYCS2 ; A3PYB1, THYX_MYCSJ ; A1UEV1, THYX_MYCSK ; DR Q1BA61, THYX_MYCSS ; A5U6A7, THYX_MYCTA ; P9WG56, THYX_MYCTO ; DR P9WG57, THYX_MYCTU ; A1T7Q0, THYX_MYCVP ; O41156, THYX_PBCV1 ; DR A8F7Q7, THYX_PSELT ; Q9UZ51, THYX_PYRAB ; Q8ZWD6, THYX_PYRAE ; DR Q8U3C9, THYX_PYRFU ; O58498, THYX_PYRHO ; Q1RJV8, THYX_RICBR ; DR Q92IL5, THYX_RICCN ; Q4UM78, THYX_RICFE ; Q9ZDM6, THYX_RICPR ; DR Q68X70, THYX_RICTY ; Q5LTY7, THYX_RUEPO ; Q980H6, THYX_SACS2 ; DR Q82K86, THYX_STRAW ; O86840, THYX_STRCO ; Q4J6F2, THYX_SULAC ; DR Q96YF6, THYX_SULTO ; P73053, THYX_SYNY3 ; B7IF44, THYX_THEAB ; DR Q5JI17, THYX_THEKO ; A6LP90, THYX_THEM4 ; Q9WYT0, THYX_THEMA ; DR B9KBK3, THYX_THENN ; B6YTN5, THYX_THEON ; A5IJX2, THYX_THEP1 ; DR B1L944, THYX_THESQ ; Q72JN9, THYX_THET2 ; Q5SJB8, THYX_THET8 ; DR Q73QY2, THYX_TREDE ; O83971, THYX_TREPA ; Q83HF9, THYX_TROW8 ; DR Q83MS7, THYX_TROWT ; Q73FX5, THYX_WOLPM ; Q7MQK8, THYX_WOLSU ; //