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ENZYME entry: EC 2.1.1.152

Accepted Name
Precorrin-6A synthase (deacetylating).
Alternative Name(s)
Precorrin-6X synthase (deacetylating).
Reaction catalysed
S-adenosyl-L-methionine + precorrin-5 + H(2)O <=> S-adenosyl-L-homocysteine + precorrin-6A + acetate
Comment(s)
  • In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
  • The first of the four steps is carried out by EC 1.14.13.83 (CobG), yielding precorrin-3B as the product.
  • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.
Cross-references
BRENDA2.1.1.152
EC2PDB2.1.1.152
ExplorEnz2.1.1.152
PRIAM enzyme-specific profiles2.1.1.152
KEGG Ligand Database for Enzyme Nomenclature2.1.1.152
IUBMB Enzyme Nomenclature2.1.1.152
IntEnz2.1.1.152
MEDLINEFind literature relating to 2.1.1.152
MetaCyc2.1.1.152
UniProtKB/Swiss-Prot
P21636, COBF_PSEDE

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