ID 2.1.1.152 DE precorrin-6A synthase (deacetylating). AN precorrin-6X synthase (deacetylating). CA H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + CA precorrin-6A + S-adenosyl-L-homocysteine. CC -!- The enzyme, which participates in the aerobic (late cobalt insertion) CC cobalamin biosythesis pathway, catalyzes two reactions - the CC methylation of carbon C(1) of precorrin-5, and its deacetylation, CC forming precorrin-6A. CC -!- See EC 2.1.1.195 for the C(1)-methyltransferase that participates in CC the anaerobic cobalamin biosynthesis pathway. DR P21636, COBF_SINSX ; //