ENZYME entry: EC 2.1.1.156

Accepted Name
Glycine/sarcosine N-methyltransferase.
Alternative Name(s)
Glycine sarcosine N-methyltransferase.
Glycine-sarcosine methyltransferase.
GMT.
GSMT.
Reaction catalysed
2 S-adenosyl-L-methionine + glycine <=> 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine
Comment(s)
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
  • Differs from EC 2.1.1.20, as it can further methylate the product of the first reaction.
  • Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction.
Cross-references
BRENDA2.1.1.156
EC2PDB2.1.1.156
ExplorEnz2.1.1.156
PRIAM enzyme-specific profiles2.1.1.156
KEGG Ligand Database for Enzyme Nomenclature2.1.1.156
IUBMB Enzyme Nomenclature2.1.1.156
IntEnz2.1.1.156
MEDLINEFind literature relating to 2.1.1.156
MetaCyc2.1.1.156
UniProtKB/Swiss-Prot
Q9KJ20, GSDMT_ACTHA;  Q83WC4, GSMT_APHHA;  Q9KJ22, GSMT_HALHR;  
Q7U4Z8, GSMT_SYNPX;  

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