ENZYME entry: EC 2.1.1.158

Accepted Name
7-methylxanthosine synthase.
Alternative Name(s)
Xanthosine methyltransferase.
XMT.
XRS1.
Reaction catalysed
S-adenosyl-L-methionine + xanthosine <=> S-adenosyl-L-homocysteine + 7-methylxanthosine
Comment(s)
  • The enzyme is specific for xanthosine, as XMP and xanthine cannot act as substrates.
  • The enzyme does not have N(1)- or N(3)- methylation activity.
  • This is the first methylation step in the production of caffeine.
Cross-references
BRENDA2.1.1.158
EC2PDB2.1.1.158
ExplorEnz2.1.1.158
PRIAM enzyme-specific profiles2.1.1.158
KEGG Ligand Database for Enzyme Nomenclature2.1.1.158
IUBMB Enzyme Nomenclature2.1.1.158
IntEnz2.1.1.158
MEDLINEFind literature relating to 2.1.1.158
MetaCyc2.1.1.158
UniProtKB/Swiss-Prot
Q9AVK0, XMT1_COFAR;  A4GE69, XMT1_COFCA;  

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