ENZYME entry: EC 2.1.1.159

Accepted Name
Theobromine synthase.
Alternative Name(s)
Monomethylxanthine methyltransferase.
MXMT.
Reaction catalysed
S-adenosyl-L-methionine + 7-methylxanthine <=> S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
Comment(s)
  • Can also catalyze the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
  • This is the third enzyme in the caffeine biosynthesis pathway.
Cross-references
BRENDA2.1.1.159
EC2PDB2.1.1.159
ExplorEnz2.1.1.159
PRIAM enzyme-specific profiles2.1.1.159
KEGG Ligand Database for Enzyme Nomenclature2.1.1.159
IUBMB Enzyme Nomenclature2.1.1.159
IntEnz2.1.1.159
MEDLINEFind literature relating to 2.1.1.159
MetaCyc2.1.1.159
UniProtKB/Swiss-Prot
Q8H0G0, CTS2_COFAR;  Q9AVJ9, MXMT1_COFAR;  Q84PP7, MXMT2_COFAR;  

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