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ENZYME entry: EC 2.1.1.188

Accepted Name
23S rRNA (guanine(748)-N(1))-methyltransferase.
Alternative Name(s)
23S rRNA m(1)G(748) methyltransferase.
rRNA large subunit methyltransferase II.
Tylosin-resistance methyltransferase RlmA(II).
Reaction catalysed
S-adenosyl-L-methionine + guanine(748) in 23S rRNA <=> S-adenosyl-L-homocysteine + N(1)-methylguanine(748) in 23S rRNA
Comment(s)
  • The enzyme specifically methylates guanine(748) at N(1) in 23S rRNA.
  • The methyltransferase RlmA(II) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae.
  • Formerly EC 2.1.1.51.
Cross-references
BRENDA2.1.1.188
EC2PDB2.1.1.188
ExplorEnz2.1.1.188
PRIAM enzyme-specific profiles2.1.1.188
KEGG Ligand Database for Enzyme Nomenclature2.1.1.188
IUBMB Enzyme Nomenclature2.1.1.188
IntEnz2.1.1.188
MEDLINEFind literature relating to 2.1.1.188
MetaCyc2.1.1.188
UniProtKB/Swiss-Prot
Q9S1M6, RLMA2_STRFR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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