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ENZYME entry: EC

Accepted Name
23S rRNA (guanine(748)-N(1))-methyltransferase.
Alternative Name(s)
23S rRNA m(1)G(748) methyltransferase.
rRNA large subunit methyltransferase II.
Tylosin-resistance methyltransferase RlmA(II).
Reaction catalysed
S-adenosyl-L-methionine + guanine(748) in 23S rRNA <=> S-adenosyl-L-homocysteine + N(1)-methylguanine(748) in 23S rRNA
  • The enzyme specifically methylates guanine(748) at N(1) in 23S rRNA.
  • The methyltransferase RlmA(II) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae.
  • Formerly EC
PRIAM enzyme-specific profiles2.1.1.188
KEGG Ligand Database for Enzyme Nomenclature2.1.1.188
IUBMB Enzyme Nomenclature2.1.1.188
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