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ENZYME entry: EC 18.104.22.168
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|tRNA methyltransferase L.|
- S-adenosyl-L-methionine + cytidine(34) in tRNA <=> S-adenosyl-L-homocysteine + 2'-O-methylcytidine(34) in tRNA
- S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) <=> S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu)
- The enzyme from Escherichia coli catalyzes the 2'-O-methylation of
cytidine or 5-carboxymethylaminomethyluridine at the wobble position
at nucleotide 34 in tRNA(Leu)CmAA and tRNA(Leu)cmnm(5)UmAA.
- The enzyme is selective for the two tRNA(Leu) isoacceptors and only
methylates these when they present the correct anticodon loop
sequence and modification pattern.
- Specifically, YibK requires a pyrimidine nucleoside at position 34,
it has a clear preference for an adenosine at position 35, and it
fails to methylate without prior addition of the N(6)-(isopentenyl)-
2-methylthioadenosine modification at position 37.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
|A1WBM9, TRML_ACISJ; ||A0KEQ6, TRML_AERHH; ||O31590, TRML_BACSU; |
|B2IBT9, TRML_BEII9; ||A0KAS4, TRML_BURCH; ||Q0BBL1, TRML_BURCM; |
|A3NR15, TRML_BURP0; ||P0AGJ8, TRML_ECOL6; ||P0AGJ7, TRML_ECOLI; |
|P32813, TRML_GEOSE; ||P44868, TRML_HAEIN; ||Q042B4, TRML_LACGA; |
|A2RKW7, TRML_LACLM; ||P69001, TRML_LISIN; ||Q721N0, TRML_LISMF; |
|C6X9I5, TRML_METGS; ||P47588, TRML_MYCGE; ||P75257, TRML_MYCPN; |
|C7BSD3, TRML_PHOAA; ||Q12E50, TRML_POLSJ; ||Q21LN7, TRML_SACD2; |
|B8CHC9, TRML_SHEPW; ||D7A3L6, TRML_STAND; ||Q48V41, TRML_STRPM; |
|P74516, TRML_SYNY3; ||Q74Y93, TRML_YERPE; |
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entries corresponding to 2.1.1.-
entries corresponding to 2.1.-.-
entries corresponding to 2.-.-.-