ENZYME entry: EC 2.1.1.208

Accepted Name
23S rRNA (uridine(2479)-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> S-adenosyl-L-homocysteine + 2'-O-methyluridine(2479) in 23S rRNA
Comment(s)
  • Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.
  • To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine(2479)-2'-O)- methyltransferase and EC 2.1.1.209 whose actions confer avilamycin resistance to the RNA.
Cross-references
BRENDA2.1.1.208
EC2PDB2.1.1.208
ExplorEnz2.1.1.208
PRIAM enzyme-specific profiles2.1.1.208
KEGG Ligand Database for Enzyme Nomenclature2.1.1.208
IUBMB Enzyme Nomenclature2.1.1.208
IntEnz2.1.1.208
MEDLINEFind literature relating to 2.1.1.208
MetaCyc2.1.1.208
UniProtKB/Swiss-Prot
Q9F5K6, AVRB_STRVR

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