ID 2.1.1.208 DE 23S rRNA (uridine(2479)-2'-O)-methyltransferase. CA S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O- CA methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine. CC -!- Streptomyces viridochromogenes produces the antibiotic avilamycin A CC which binds to the 50S ribosomal subunit to inhibit protein CC synthesis. CC -!- To protect itself from the antibiotic, Streptomyces viridochromogenes CC utilizes two methyltransferases, 23S rRNA (uridine(2479)-2'-O)- CC methyltransferase and EC 2.1.1.209 whose actions confer avilamycin CC resistance to the RNA. DR Q9F5K6, AVRB_STRVR ; //