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ENZYME entry: EC 2.1.1.209

Accepted Name
23S rRNA (guanine(2535)-N(1))-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + guanine(2535) in 23S rRNA <=> S-adenosyl-L-homocysteine + N(1)-methylguanine(2535) in 23S rRNA
Comment(s)
  • Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.
  • To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- methyltransferase and EC 2.1.1.208 whose actions confer avilamycin resistance to the RNA.
Cross-references
BRENDA2.1.1.209
EC2PDB2.1.1.209
ExplorEnz2.1.1.209
PRIAM enzyme-specific profiles2.1.1.209
KEGG Ligand Database for Enzyme Nomenclature2.1.1.209
IUBMB Enzyme Nomenclature2.1.1.209
IntEnz2.1.1.209
MEDLINEFind literature relating to 2.1.1.209
MetaCyc2.1.1.209
UniProtKB/Swiss-Prot
Q9F5K5, AVRA_STRVR

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