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ENZYME entry: EC

Accepted Name
23S rRNA (guanine(2535)-N(1))-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + guanine(2535) in 23S rRNA <=> S-adenosyl-L-homocysteine + N(1)-methylguanine(2535) in 23S rRNA
  • Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.
  • To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- methyltransferase and EC whose actions confer avilamycin resistance to the RNA.
PRIAM enzyme-specific profiles2.1.1.209
KEGG Ligand Database for Enzyme Nomenclature2.1.1.209
IUBMB Enzyme Nomenclature2.1.1.209
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