ID 2.1.1.209 DE 23S rRNA (guanine(2535)-N(1))-methyltransferase. CA guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)- CA methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine. CC -!- Streptomyces viridochromogenes produces the antibiotic avilamycin A CC which binds to the 50S ribosomal subunit to inhibit protein CC synthesis. CC -!- To protect itself from the antibiotic, Streptomyces viridochromogenes CC utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- CC methyltransferase and EC 2.1.1.208 whose actions confer avilamycin CC resistance to the RNA. DR Q9F5K5, AVRA_STRVR ; //