ENZYME entry: EC 2.1.1.225

Accepted Name
tRNA:m(4)X modification enzyme.
Reaction catalysed
  • S-adenosyl-L-methionine + cytidine(4) in tRNA(Pro) <=> S-adenosyl-L-homocysteine + 2'-O-methylcytidine(4) in tRNA(Pro)
  • S-adenosyl-L-methionine + cytidine(4) in tRNA(Gly)(GCC) <=> S-adenosyl-L-homocysteine + 2'-O-methylcytidine(4) in tRNA(Gly)(GCC)
  • S-adenosyl-L-methionine + adenosine(4) in tRNA(His) <=> S-adenosyl-L-homocysteine + 2'-O-methyladenosine(4) in tRNA(His)
Comment(s)
The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Cross-references
BRENDA2.1.1.225
EC2PDB2.1.1.225
ExplorEnz2.1.1.225
PRIAM enzyme-specific profiles2.1.1.225
KEGG Ligand Database for Enzyme Nomenclature2.1.1.225
IUBMB Enzyme Nomenclature2.1.1.225
IntEnz2.1.1.225
MEDLINEFind literature relating to 2.1.1.225
MetaCyc2.1.1.225
UniProtKB/Swiss-Prot
Q75AT3, TRM13_ASHGO;  Q6BP10, TRM13_DEBHA;  Q54BD5, TRM13_DICDI;  
Q9NUP7, TRM13_HUMAN;  Q6CP50, TRM13_KLULA;  Q8BYH3, TRM13_MOUSE;  
A3LXS6, TRM13_PICST;  Q9UTH1, TRM13_SCHPO;  A7TSF4, TRM13_VANPO;  
Q6C4F8, TRM13_YARLI;  Q12383, TRM13_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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