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ENZYME entry: EC 2.1.1.226

Accepted Name
23S rRNA (cytidine(1920)-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + cytidine(1920) in 23S rRNA <=> S-adenosyl-L-homocysteine + 2'-O-methylcytidine(1920) in 23S rRNA
Comment(s)
  • The bifunctional enzyme from Mycobacterium tuberculosis 2'-O- methylates cytidine(1920) in helix 69 of 23S rRNA and cytidine(1409) in helix 44 of 16S rRNA (cf. EC 2.1.1.227).
  • These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
Cross-references
BRENDA2.1.1.226
EC2PDB2.1.1.226
ExplorEnz2.1.1.226
PRIAM enzyme-specific profiles2.1.1.226
KEGG Ligand Database for Enzyme Nomenclature2.1.1.226
IUBMB Enzyme Nomenclature2.1.1.226
IntEnz2.1.1.226
MEDLINEFind literature relating to 2.1.1.226
MetaCyc2.1.1.226
UniProtKB/Swiss-Prot
P9WJ62, TLYA_MYCTO;  P9WJ63, TLYA_MYCTU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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