ENZYME entry: EC 2.1.1.239

Accepted Name
L-olivosyl-oleandolide 3-O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + L-olivosyl-oleandolide <=> S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide
Comment(s)
  • The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus.
  • It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B.
Cross-references
BRENDA2.1.1.239
EC2PDB2.1.1.239
ExplorEnz2.1.1.239
PRIAM enzyme-specific profiles2.1.1.239
KEGG Ligand Database for Enzyme Nomenclature2.1.1.239
IUBMB Enzyme Nomenclature2.1.1.239
IntEnz2.1.1.239
MEDLINEFind literature relating to 2.1.1.239
MetaCyc2.1.1.239
UniProtKB/Swiss-Prot
O87833, OLEY_STRAT

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