ID   2.1.1.244
DE   protein N-terminal methyltransferase.
CA   (1) N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-
CA   methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-
CA   lysyl-[protein] + 3 S-adenosyl-L-homocysteine.
CA   (2) N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-
CA   methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-
CA   lysyl-[protein] + 3 S-adenosyl-L-homocysteine.
CA   (3) N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-
CA   methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-
CA   [protein] + 2 S-adenosyl-L-homocysteine.
CC   -!- This enzyme methylates the N-terminus of target proteins containing
CC       the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator
CC       L-methionine is cleaved.
CC   -!- When the terminal amino acid is L-proline, the enzyme catalyzes two
CC       successive methylations of its alpha-amino group.
CC   -!- When the first amino acid is either L-alanine or L-serine, the enzyme
CC       catalyzes three successive methylations.
CC   -!- The Pro-Lys in positions 2-3 cannot be exchanged for other amino
CC       acids.
CC   -!- Formerly EC 2.1.1.n5.
DR   Q4KL94, NT1AA_XENLA;  Q4KLE6, NT1AB_XENLA;  D2H163, NTM1A_AILME;
DR   Q2T9N3, NTM1A_BOVIN;  Q6NWX7, NTM1A_DANRE;  Q9BV86, NTM1A_HUMAN;
DR   Q8R2U4, NTM1A_MOUSE;  Q5BJX0, NTM1A_RAT  ;  B1H2P7, NTM1A_XENTR;
DR   Q5PP70, NTM1_ARATH ;  A8WVR2, NTM1_CAEBR ;  Q9N4D9, NTM1_CAEEL ;
DR   Q55DH6, NTM1_DICDI ;  Q6NN40, NTM1_DROME ;  A2XMJ1, NTM1_ORYSI ;
DR   Q10CT5, NTM1_ORYSJ ;  O13748, NTM1_SCHPO ;  P38340, NTM1_YEAST ;
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