ENZYME entry: EC 18.104.22.168
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|Methylated-thiol--coenzyme M methyltransferase.
|Methanethiol + coenzyme M <=> methyl-CoM + hydrogen sulfide|
- The enzyme, which is involved in methanogenesis from methylated
thiols, such as methane thiol, dimethyl sulfide, and 3-S-
methylmercaptopropionate, catalyzes two successive steps - the
transfer of a methyl group from the substrate to the cobalt cofactor
of a methylated-thiol-specific corrinoid protein (MtsB), and the
subsequent transfer of the methyl group from the corrinoid protein to
- With most other methanogenesis substrates this process is carried out
by two different enzymes (for example, EC 22.214.171.124 and EC 126.96.36.199).
- The cobalt is oxidized during methylation from the Co(I) state to the
Co(III) state, and is reduced back to the Co(I) form during
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
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