ID 2.1.1.251 DE methylated-thiol--coenzyme M methyltransferase. CA coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M. CC -!- The enzyme, which is involved in methanogenesis from methylated CC thiols, such as methane thiol, dimethyl sulfide, CC and 3-(methylsulfanyl)propanoate, catalyzes two successive steps - CC the transfer of a methyl group from the substrate to the cobalt CC cofactor of a methylated-thiol-specific corrinoid protein (MtsB), CC and the subsequent transfer of the methyl group from the corrinoid CC protein to coenzyme M. CC -!- With most other methanogenesis substrates this process is carried out CC by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246). CC -!- The cobalt is oxidized during methylation from the Co(I) state to the CC Co(III) state, and is reduced back to the Co(I) form during CC demethylation. DR Q48924, MTSA_METBA ; Q8PUA8, MTSA_METMA ; //