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ENZYME entry: EC

Accepted Name
Erythromycin 3''-O-methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A
  • S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B
  • The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A.
  • It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC
PRIAM enzyme-specific profiles2.1.1.254
KEGG Ligand Database for Enzyme Nomenclature2.1.1.254
IUBMB Enzyme Nomenclature2.1.1.254
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