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ENZYME entry: EC 2.1.1.254

Accepted Name
Erythromycin 3''-O-methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A
  • S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B
Comment(s)
  • The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A.
  • It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154.
Cross-references
BRENDA2.1.1.254
EC2PDB2.1.1.254
ExplorEnz2.1.1.254
PRIAM enzyme-specific profiles2.1.1.254
KEGG Ligand Database for Enzyme Nomenclature2.1.1.254
IUBMB Enzyme Nomenclature2.1.1.254
IntEnz2.1.1.254
MEDLINEFind literature relating to 2.1.1.254
MetaCyc2.1.1.254
UniProtKB/Swiss-Prot
A4F7P5, ERYG_SACEN

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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