ENZYME entry: EC 2.1.1.260

Accepted Name
rRNA small subunit pseudouridine methyltransferase Nep1.
Reaction catalysed
S-adenosyl-L-methionine + pseudouridine(1191) in yeast 18S rRNA <=> S-adenosyl-L-homocysteine + N(1)-methylpseudouridine(1191) in yeast 18S rRNA
Comment(s)
  • This enzyme, which occurs in both prokaryotes and eukaryotes, recognizes specific pseudouridine residues (Psi) in small subunits of ribosomal RNA based on the local RNA structure.
  • It recognizes Psi(914) in 16S rRNA from the archaeon Methanocaldococcus jannaschii, Psi(1191) in yeast 18S rRNA, and Psi(1248) in human 18S rRNA.
Cross-references
BRENDA2.1.1.260
EC2PDB2.1.1.260
ExplorEnz2.1.1.260
PRIAM enzyme-specific profiles2.1.1.260
KEGG Ligand Database for Enzyme Nomenclature2.1.1.260
IUBMB Enzyme Nomenclature2.1.1.260
IntEnz2.1.1.260
MEDLINEFind literature relating to 2.1.1.260
MetaCyc2.1.1.260
UniProtKB/Swiss-Prot
Q9P8P7, NEP1_CANAX;  Q96UP2, NEP1_CANGA;  Q06287, NEP1_YEAST;  

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