ENZYME entry: EC 2.1.1.264

Accepted Name
23S rRNA (guanine(2069)-N(7))-methyltransferase.
Alternative Name(s)
23S rRNA m(7)G(2069) methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA <=> S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA
Comment(s)
  • The enzyme specifically methylates guanine(2069) at position N7 in 23S rRNA.
  • In gamma-proteobacteria the enzyme also catalyzes EC 2.1.1.173, while in beta-proteobacteria the activities are carried out by separate proteins.
  • The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well.
Cross-references
BRENDA2.1.1.264
EC2PDB2.1.1.264
ExplorEnz2.1.1.264
PRIAM enzyme-specific profiles2.1.1.264
KEGG Ligand Database for Enzyme Nomenclature2.1.1.264
IUBMB Enzyme Nomenclature2.1.1.264
IntEnz2.1.1.264
MEDLINEFind literature relating to 2.1.1.264
MetaCyc2.1.1.264
UniProtKB/Swiss-Prot
Q6FCR7, RLMKL_ACIAD;  B2HWX8, RLMKL_ACIBC;  B0VLH0, RLMKL_ACIBS;  
B0VAL5, RLMKL_ACIBY;  A3MYD2, RLMKL_ACTP2;  B3GZQ0, RLMKL_ACTP7;  
B0BRL8, RLMKL_ACTPJ;  A6VMR3, RLMKL_ACTSZ;  A0KKK7, RLMKL_AERHH;  
A4SME4, RLMKL_AERS4;  Q0VQU5, RLMKL_ALCBS;  B6ELD3, RLMKL_ALISL;  
Q0A793, RLMKL_ALKEH;  Q1W3E0, RLMKL_ALLVD;  B4RZ48, RLMKL_ALTMD;  
P57444, RLMKL_BUCAI;  Q8K9I4, RLMKL_BUCAP;  B3PIL6, RLMKL_CELJU;  
Q1QXV9, RLMKL_CHRSD;  A8AID1, RLMKL_CITK8;  Q47Z09, RLMKL_COLP3;  
A7MEX5, RLMKL_CROS8;  Q6AQA5, RLMKL_DESPS;  A5EX48, RLMKL_DICNV;  
A7ZK52, RLMKL_ECO24;  Q8XDB2, RLMKL_ECO57;  B5YT79, RLMKL_ECO5E;  
B1X8Q2, RLMKL_ECODH;  A7ZYQ0, RLMKL_ECOHS;  A1A9L8, RLMKL_ECOK1;  
Q0TJB3, RLMKL_ECOL5;  Q8FJ88, RLMKL_ECOL6;  B1IVY4, RLMKL_ECOLC;  
P75864, RLMKL_ECOLI;  B1LJR4, RLMKL_ECOSM;  Q1RDR6, RLMKL_ECOUT;  
A4W8W0, RLMKL_ENT38;  B2VDF6, RLMKL_ERWT9;  B0U0U4, RLMKL_FRAP2;  
Q14HS5, RLMKL_FRAT1;  A7NCY2, RLMKL_FRATF;  Q2A2U4, RLMKL_FRATH;  
B2SGG3, RLMKL_FRATM;  A0Q621, RLMKL_FRATN;  Q0BLC3, RLMKL_FRATO;  
Q5NGC3, RLMKL_FRATT;  A4IXN4, RLMKL_FRATW;  Q7VP04, RLMKL_HAEDU;  
Q4QP66, RLMKL_HAEI8;  A5UB28, RLMKL_HAEIE;  A5UFS2, RLMKL_HAEIG;  
P44524, RLMKL_HAEIN;  Q0I4C6, RLMKL_HAES1;  Q2SCH1, RLMKL_HAHCH;  
B0UUM5, RLMKL_HISS2;  Q5QX63, RLMKL_IDILO;  B5XY56, RLMKL_KLEP3;  
A6T742, RLMKL_KLEP7;  Q5X969, RLMKL_LEGPA;  A5I9H3, RLMKL_LEGPC;  
Q5ZZI8, RLMKL_LEGPH;  Q5X0J6, RLMKL_LEGPL;  A0L8B5, RLMKL_MAGMM;  
Q65UK6, RLMKL_MANSM;  A1TZG2, RLMKL_MARHV;  A6VW36, RLMKL_MARMS;  
Q60AX5, RLMKL_METCA;  Q9CNW9, RLMKL_PASMU;  Q6D459, RLMKL_PECAS;  
Q3A2U5, RLMKL_PELCD;  Q7N612, RLMKL_PHOLL;  Q6LRA0, RLMKL_PHOPR;  
B4EVC6, RLMKL_PROMH;  Q48JX8, RLMKL_PSE14;  Q15UB5, RLMKL_PSEA6;  
A6V328, RLMKL_PSEA7;  Q9HZG0, RLMKL_PSEAE;  Q1ICL2, RLMKL_PSEE4;  
Q4KFI6, RLMKL_PSEF5;  Q3IGZ3, RLMKL_PSEHT;  A4XWP8, RLMKL_PSEMY;  
A5W6K7, RLMKL_PSEP1;  Q3KFC5, RLMKL_PSEPF;  B0KG92, RLMKL_PSEPG;  
Q88L39, RLMKL_PSEPK;  B1J5B7, RLMKL_PSEPW;  Q883N9, RLMKL_PSESM;  
Q4ZUM1, RLMKL_PSEU2;  A4VM39, RLMKL_PSEU5;  Q4FTN9, RLMKL_PSYA2;  
Q1QCP8, RLMKL_PSYCK;  A1SX09, RLMKL_PSYIN;  A5WGC0, RLMKL_PSYWF;  
Q21JW7, RLMKL_SACD2;  B5F1U5, RLMKL_SALA4;  A9MHU0, RLMKL_SALAR;  
Q57QU1, RLMKL_SALCH;  B5FQZ1, RLMKL_SALDC;  B5QZF1, RLMKL_SALEP;  
B5R6B4, RLMKL_SALG2;  B4TDY8, RLMKL_SALHS;  B4T1Z1, RLMKL_SALNS;  
Q5PGE3, RLMKL_SALPA;  A9N6Y0, RLMKL_SALPB;  B5BBL9, RLMKL_SALPK;  
B4TRX1, RLMKL_SALSV;  Q8Z7S6, RLMKL_SALTI;  Q8ZQ73, RLMKL_SALTY;  
A8GCK7, RLMKL_SERP5;  A1S601, RLMKL_SHEAM;  A3D5Q0, RLMKL_SHEB5;  
A6WPK6, RLMKL_SHEB8;  A9L591, RLMKL_SHEB9;  Q12LC6, RLMKL_SHEDO;  
Q07ZR3, RLMKL_SHEFN;  B0TIX7, RLMKL_SHEHH;  A3QDY0, RLMKL_SHELP;  
Q8EFW4, RLMKL_SHEON;  A8H3Y1, RLMKL_SHEPA;  A4Y5X4, RLMKL_SHEPC;  
A0KVL6, RLMKL_SHESA;  A8FW59, RLMKL_SHESH;  Q0HJZ9, RLMKL_SHESM;  
Q0HWA0, RLMKL_SHESR;  A1RKM2, RLMKL_SHESW;  B1KDN0, RLMKL_SHEWM;  
B2TUD1, RLMKL_SHIB3;  Q31YL1, RLMKL_SHIBS;  Q32HV8, RLMKL_SHIDS;  
Q0T686, RLMKL_SHIF8;  Q83RX5, RLMKL_SHIFL;  Q3Z3H3, RLMKL_SHISS;  
Q2NU80, RLMKL_SODGM;  B4SQ79, RLMKL_STRM5;  B2FJ58, RLMKL_STRMK;  
Q31IC8, RLMKL_THICR;  A5F836, RLMKL_VIBC3;  A7N0M8, RLMKL_VIBCB;  
Q9KRZ5, RLMKL_VIBCH;  Q5E5B4, RLMKL_VIBF1;  B5FE19, RLMKL_VIBFM;  
Q87PC0, RLMKL_VIBPA;  Q7MKX1, RLMKL_VIBVY;  Q8PM40, RLMKL_XANAC;  
Q3BV47, RLMKL_XANC5;  Q4UT85, RLMKL_XANC8;  B0RV07, RLMKL_XANCB;  
Q8PAE0, RLMKL_XANCP;  Q2P309, RLMKL_XANOM;  B2SIS8, RLMKL_XANOP;  
Q5H029, RLMKL_XANOR;  B2IA87, RLMKL_XYLF2;  Q9PA69, RLMKL_XYLFA;  
B0U5Z5, RLMKL_XYLFM;  Q87A16, RLMKL_XYLFT;  A1JMQ6, RLMKL_YERE8;  
A7FJT9, RLMKL_YERP3;  Q1CA41, RLMKL_YERPA;  B2JYS1, RLMKL_YERPB;  
Q7CHK7, RLMKL_YERPE;  A9R7L5, RLMKL_YERPG;  Q1CGJ3, RLMKL_YERPN;  
A4TMZ0, RLMKL_YERPP;  Q66CG1, RLMKL_YERPS;  B1JQR7, RLMKL_YERPY;  
Q9JYY8, RLMK_NEIMB;  

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