ENZYME entry: EC 2.1.1.281

Accepted Name
Phenylpyruvate C(3)-methyltransferase.
Alternative Name(s)
Phenylpyruvate C-beta-methyltransferase.
Phenylpyruvate methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + 3-phenylpyruvate <=> S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate
Comment(s)
The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)- beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
Cross-references
BRENDA2.1.1.281
EC2PDB2.1.1.281
ExplorEnz2.1.1.281
PRIAM enzyme-specific profiles2.1.1.281
KEGG Ligand Database for Enzyme Nomenclature2.1.1.281
IUBMB Enzyme Nomenclature2.1.1.281
IntEnz2.1.1.281
MEDLINEFind literature relating to 2.1.1.281
MetaCyc2.1.1.281
UniProtKB/Swiss-Prot
Q643C8, MPPJ_STRHY

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