ENZYME entry: EC 2.1.1.282

Accepted Name
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))- methyltransferase.
Alternative Name(s)
tRNA-yW synthesizing enzyme-3.
Reaction catalysed
S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) <=> S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe)
Comment(s)
  • The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs.
  • These modifications are important for translational reading-frame maintenance.
  • The enzyme is found in all eukaryotes and in some archaea, but not in bacteria.
  • The eukaryotic enzyme is involved in the biosynthesis of wybutosine.
Cross-references
BRENDA2.1.1.282
EC2PDB2.1.1.282
ExplorEnz2.1.1.282
PRIAM enzyme-specific profiles2.1.1.282
KEGG Ligand Database for Enzyme Nomenclature2.1.1.282
IUBMB Enzyme Nomenclature2.1.1.282
IntEnz2.1.1.282
MEDLINEFind literature relating to 2.1.1.282
MetaCyc2.1.1.282
UniProtKB/Swiss-Prot
Q8W4K1, TYW23_ARATH;  Q8H4D4, TYW23_ORYSJ;  Q9V074, TYW31_PYRAB;  
Q8U1V7, TYW31_PYRFU;  O58796, TYW31_PYRHO;  Q5JFK6, TYW31_THEKO;  
Q9V1Y5, TYW32_PYRAB;  Q8TZG0, TYW32_PYRFU;  O59533, TYW32_PYRHO;  
Q5JES6, TYW32_THEKO;  Q9YDV3, TYW3_AERPE;  O28220, TYW3_ARCFU;  
Q5E9U4, TYW3_BOVIN;  Q6DHJ1, TYW3_DANRE;  Q6IPR3, TYW3_HUMAN;  
Q58905, TYW3_METJA;  Q8BSA9, TYW3_MOUSE;  Q19QT9, TYW3_PIG;  
Q5R5S9, TYW3_PONAB;  Q9UTA5, TYW3_SCHPO;  Q9UX16, TYW3_SULSO;  
C6A5A3, TYW3_THESM;  Q641F8, TYW3_XENLA;  P53177, TYW3_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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