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ENZYME entry: EC 2.1.1.290

Accepted Name
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase.
Alternative Name(s)
tRNA-yW synthesizing enzyme-4.
Reaction catalysed
S-adenosyl-L-methionine + 7-((3S)-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) <=> S-adenosyl-L-homocysteine + 7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe)
Comment(s)
  • The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
  • The modification is important for translational reading-frame maintenance.
  • In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) as substrate.
  • The enzyme also has the activity of EC 2.3.1.231.
Cross-references
BRENDA2.1.1.290
EC2PDB2.1.1.290
ExplorEnz2.1.1.290
PRIAM enzyme-specific profiles2.1.1.290
KEGG Ligand Database for Enzyme Nomenclature2.1.1.290
IUBMB Enzyme Nomenclature2.1.1.290
IntEnz2.1.1.290
MEDLINEFind literature relating to 2.1.1.290
MetaCyc2.1.1.290
UniProtKB/Swiss-Prot
Q75AW4, TYW4_ASHGO;  Q4WVD1, TYW4_ASPFU;  Q2U6D4, TYW4_ASPOR;  
Q5A931, TYW4_CANAL;  Q6FXA5, TYW4_CANGA;  Q5BH52, TYW4_EMENI;  
Q4IER0, TYW4_GIBZE;  O60294, TYW4_HUMAN;  Q8BYR1, TYW4_MOUSE;  
Q9P3K9, TYW4_NEUCR;  Q5XIA3, TYW4_RAT;  O60157, TYW4_SCHPO;  
Q6C3P4, TYW4_YARLI;  Q08282, TYW4_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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