ENZYME entry: EC 22.214.171.1246
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|S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] <=> S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]|
- The enzyme, found in higher eukaryotes including insects and
vertebrates, and their viruses, methylates the ribose of the
nucleoside at the second transcribed position of mRNAs and snRNAs.
- This methylation is known as cap2.
- The human enzyme can also methylate mRNA molecules where the upstream
purine ribonucleotide is not methylated (see EC 126.96.36.199), but with
|PRIAM enzyme-specific profiles||188.8.131.526|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.2066|
|IUBMB Enzyme Nomenclature||220.127.116.116|
|MEDLINE||Find literature relating to 18.104.22.1686|
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