ENZYME entry: EC 2.1.1.296

Accepted Name
Methyltransferase cap2.
Alternative Name(s)
Cap2-MTase.
mRNA (nucleoside-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] <=> S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
Comment(s)
  • The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the nucleoside at the second transcribed position of mRNAs and snRNAs.
  • This methylation is known as cap2.
  • The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57), but with lower efficiency.
Cross-references
BRENDA2.1.1.296
EC2PDB2.1.1.296
ExplorEnz2.1.1.296
PRIAM enzyme-specific profiles2.1.1.296
KEGG Ligand Database for Enzyme Nomenclature2.1.1.296
IUBMB Enzyme Nomenclature2.1.1.296
IntEnz2.1.1.296
MEDLINEFind literature relating to 2.1.1.296
MetaCyc2.1.1.296
UniProtKB/Swiss-Prot
Q7ZVS8, CMTR2_DANRE;  Q9UAS6, CMTR2_DROME;  Q8IYT2, CMTR2_HUMAN;  
Q8BWQ4, CMTR2_MOUSE;  Q5RAY7, CMTR2_PONAB;  

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