ENZYME entry: EC 2.1.1.296

Accepted Name
Methyltransferase cap2.
Alternative Name(s)
Cap2-MTase.
mRNA (nucleoside-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] <=> S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
Comment(s)
  • The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the nucleoside at the second transcribed position of mRNAs and snRNAs.
  • This methylation is known as cap2.
  • The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57), but with lower efficiency.
Cross-references
BRENDA2.1.1.296
EC2PDB2.1.1.296
ExplorEnz2.1.1.296
PRIAM enzyme-specific profiles2.1.1.296
KEGG Ligand Database for Enzyme Nomenclature2.1.1.296
IUBMB Enzyme Nomenclature2.1.1.296
IntEnz2.1.1.296
MEDLINEFind literature relating to 2.1.1.296
MetaCyc2.1.1.296
UniProtKB/Swiss-Prot
Q7ZVS8, CMTR2_DANRE;  Q9UAS6, CMTR2_DROME;  Q8IYT2, CMTR2_HUMAN;  
Q8BWQ4, CMTR2_MOUSE;  Q5RAY7, CMTR2_PONAB;  Q9QSP0, L_ABLVB;  
Q8JTG9, L_ABLVH;  Q9E784, L_BEFVB;  P24658, L_CDVO;  
P13179, L_CHAV;  C6S3N3, L_DMSVA;  A4UHQ2, L_EBLV1;  
A4UHQ7, L_EBLV2;  Q91DD4, L_EBORE;  Q8JPX5, L_EBORR;  
Q66802, L_EBOSM;  Q5XX01, L_EBOSU;  Q6V1Q2, L_EBOZ5;  
Q05318, L_EBOZM;  O89344, L_HENDH;  Q77SJ8, L_HIRRV;  
Q82707, L_IHNVO;  Q82685, L_IHNVW;  Q5K2K3, L_ISFV;  
Q4W382, L_LNYV3;  Q1PD54, L_MABVA;  P31352, L_MABVM;  
Q6UY63, L_MABVO;  P35262, L_MABVP;  Q1PDC4, L_MABVR;  
P35975, L_MEASA;  Q9WMB3, L_MEASC;  P12576, L_MEASE;  
Q6E0W6, L_MMVR;  P0C568, L_MOKV;  P30929, L_MUMPM;  
P11205, L_NDVB;  Q9DLD3, L_NDVB1;  Q997F0, L_NIPAV;  
P26676, L_PI2HT;  P12577, L_PI3H4;  Q88434, L_PIV5;  
Q03396, L_PIV5W;  Q4F8Z9, L_RABVA;  Q66T60, L_RABVB;  
Q0GBX5, L_RABVD;  A3F5L9, L_RABVE;  Q8B6J5, L_RABVH;  
A3RM23, L_RABVI;  Q9IPJ5, L_RABVN;  P11213, L_RABVP;  
Q0GBY0, L_RABVR;  P16289, L_RABVS;  P41357, L_RINDR;  
O10378, L_RYSV;  Q9DUD8, L_SENDA;  P06829, L_SENDE;  
Q06996, L_SENDF;  O55528, L_SENDO;  P06447, L_SENDZ;  
Q9QJT4, L_SHRV;  P35341, L_SV41;  Q91DR9, L_SVCV;  
P31332, L_SYNV;  Q5GA85, L_TAVCV;  D8V078, L_TIBVC;  
Q4VKV2, L_TUPVT;  P03523, L_VSIVA;  Q8B0H0, L_VSIVC;  
Q98776, L_VSIVM;  Q8B0I0, L_VSIVN;  Q8B0H5, L_VSIVS;  
P13615, L_VSNJH;  P16379, L_VSNJO;  

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