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ENZYME

ENZYME entry: EC 2.1.1.296

Accepted Name
methyltransferase cap2
Alternative Name(s)
cap2-MTase
mRNA (nucleoside-2'-O)-methyltransferase
Reaction catalysed
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the nucleoside at the second transcribed position of mRNAs and snRNAs.
  • This methylation is known as cap2.
  • The human enzyme can also methylate mRNA molecules where the upstream ribonucleotide is not methylated (see EC 2.1.1.57), but with lower efficiency.
Cross-references
BRENDA2.1.1.296
EC2PDB2.1.1.296
ExplorEnz2.1.1.296
PRIAM enzyme-specific profiles2.1.1.296
KEGG Ligand Database for Enzyme Nomenclature2.1.1.296
IUBMB Enzyme Nomenclature2.1.1.296
IntEnz2.1.1.296
MEDLINEFind literature relating to 2.1.1.296
MetaCyc2.1.1.296
Rhea expert-curated reactions2.1.1.296
UniProtKB/Swiss-Prot
Q7ZVS8, CMTR2_DANREQ9UAS6, CMTR2_DROMEQ8IYT2, CMTR2_HUMAN
Q8BWQ4, CMTR2_MOUSEQ5RAY7, CMTR2_PONAB

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