ENZYME entry: EC 2.1.1.299

Accepted Name
Protein N-terminal monomethyltransferase.
Alternative Name(s)
N-terminal monomethylase.
Reaction catalysed
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] <=> S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Comment(s)
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved.
  • In contrast to EC 2.1.1.244, the protein only adds one methyl group to the N-terminal.
Cross-references
BRENDA2.1.1.299
EC2PDB2.1.1.299
ExplorEnz2.1.1.299
PRIAM enzyme-specific profiles2.1.1.299
KEGG Ligand Database for Enzyme Nomenclature2.1.1.299
IUBMB Enzyme Nomenclature2.1.1.299
IntEnz2.1.1.299
MEDLINEFind literature relating to 2.1.1.299
MetaCyc2.1.1.299
UniProtKB/Swiss-Prot
B8JM82, NTM1B_DANRE;  Q5VVY1, NTM1B_HUMAN;  B2RXM4, NTM1B_MOUSE;  
D3ZVR1, NTM1B_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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