ID   2.1.1.303
DE   2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase.
AN   neocarzinostatin O-methyltransferase.
CA   2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine =
CA   2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-
CA   homocysteine.
CC   -!- The enzyme from the bacterium Streptomyces carzinostaticus is
CC       involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1-
CC       naphthoate.
CC   -!- This compound is part of the enediyne chromophore of the antitumor
CC       antibiotic neocarzinostatin.
CC   -!- In vivo the enzyme catalyzes the regiospecific methylation at the
CC       7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-
CC       naphthoate.
CC   -!- In vitro it also recognizes other dihydroxynaphthoic acids and
CC       catalyzes their regiospecific O-methylation.
DR   Q84HC8, NCSB1_STRCZ;
//