ID   2.1.1.362
DE   [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
CA   N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) +
CA   N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.
CC   -!- This entry describes a group of enzymes that catalyze a single
CC       methylation of monomethylated lysine(20) of histone H4 (H4K20m1,
CC       generated by EC 2.1.1.361), forming the dimethylated form.
CC   -!- This modification is broadly distributed across the genome and is
CC       likely important for general chromatin-mediated processes.
CC   -!- The double-methylated form of lysine(20) in histone H4 is the most
CC       abundant methylation state of this residue and is found on ~80% of
CC       all histone H4 molecules.
CC   -!- Full activity of the enzyme requires that the lysine at position 9 of
CC       histone H3 is trimethylated.
DR   Q29RP8, KMT5B_BOVIN;  Q5U3H2, KMT5B_DANRE;  Q4FZB7, KMT5B_HUMAN;
DR   Q3U8K7, KMT5B_MOUSE;  P0C2N5, KMT5B_RAT  ;  Q86Y97, KMT5C_HUMAN;
DR   Q6Q783, KMT5C_MOUSE;  P0C2N6, KMT5C_RAT  ;  A0JMZ4, KMT5C_XENLA;
DR   Q6GP17, KT5BA_XENLA;  Q5RJX8, KT5BB_XENLA;  Q6P2A1, PRDM9_DANRE;
DR   Q9NQV7, PRDM9_HUMAN;  Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT  ;
DR   A8WTV9, SUV42_CAEBR;  Q09265, SUV42_CAEEL;  Q9W5E0, SUV42_DROME;
//