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ENZYME entry: EC 2.1.1.41

Accepted Name
Sterol 24-C-methyltransferase.
Alternative Name(s)
24-sterol C-methyltransferase.
Delta(24)-methyltransferase.
Delta(24)-sterol methyltransferase.
Phytosterol methyltransferase.
S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase.
S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase.
SMT1.
Zymosterol-24-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol <=> S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol
Cofactor(s)
Glutathione.
Comment(s)
  • Acts on a range of sterols with a 24(25)-double bond in the side chain.
  • While zymosterol is the preferred substrate it also acts on desmosterol, 5-alpha-cholesta-7,24-dien-3-beta-ol, 5-alpha-cholesta- 5,7,24-trien-3-beta-ol, 4-alpha-methylzymosterol and others.
  • S-adenosyl-L-methionine attacks the Si face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond.
Cross-references
BRENDA2.1.1.41
EC2PDB2.1.1.41
ExplorEnz2.1.1.41
PRIAM enzyme-specific profiles2.1.1.41
KEGG Ligand Database for Enzyme Nomenclature2.1.1.41
IUBMB Enzyme Nomenclature2.1.1.41
IntEnz2.1.1.41
MEDLINEFind literature relating to 2.1.1.41
MetaCyc2.1.1.41
UniProtKB/Swiss-Prot
Q759S7, ERG6_ASHGO;  O74198, ERG6_CANAL;  Q6FRZ7, ERG6_CANGA;  
Q875K1, ERG6_CLAL4;  Q6BRB7, ERG6_DEBHA;  Q6CYB3, ERG6_KLULA;  
P0CT10, ERG6_MAGO7;  L7IP31, ERG6_MAGOY;  Q6C2D9, ERG6_YARLI;  
P25087, ERG6_YEAST;  Q9LM02, SMT1_ARATH;  Q54I98, SMT1_DICDI;  
Q6ZIX2, SMT1_ORYSJ;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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