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ENZYME

ENZYME entry: EC 2.1.1.57

Accepted Name
methyltransferase cap1
Alternative Name(s)
cap1-MTase
messenger RNA (nucleoside-2'-)-methyltransferase
mRNA (nucleoside-2'-O)-methyltransferase
Reaction catalysed
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules.
  • This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses.
  • The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine.
  • Formerly EC 2.1.1.58.
Cross-references
BRENDA2.1.1.57
EC2PDB2.1.1.57
ExplorEnz2.1.1.57
PRIAM enzyme-specific profiles2.1.1.57
KEGG Ligand Database for Enzyme Nomenclature2.1.1.57
IUBMB Enzyme Nomenclature2.1.1.57
IntEnz2.1.1.57
MEDLINEFind literature relating to 2.1.1.57
MetaCyc2.1.1.57
Rhea expert-curated reactions2.1.1.57
UniProtKB/Swiss-Prot
D2HRF1, CMTR1_AILMEA2VE39, CMTR1_BOVINQ803R5, CMTR1_DANRE
Q9W4N2, CMTR1_DROMEQ8N1G2, CMTR1_HUMANQ9DBC3, CMTR1_MOUSE
Q5R981, CMTR1_PONABQ5U2Z5, CMTR1_RATQ6GQ76, CMTR1_XENLA
P41469, CMTR_NPVACP15916, MCE_FOWPNA0A7H0DN74, MCE_MONPV
P68544, MCE_MYXVLP68545, MCE_MYXVUP19748, MCE_SHEVK
P23334, MCE_SWPVKQ76ZT1, MCE_VACCAP21033, MCE_VACCC
P07617, MCE_VACCWP33052, MCE_VAR67A8XYX2, MTR1A_CAEBR
Q9NAA5, MTR1_CAEELQ54WR1, MTR1_DICDIA4HQI9, MTR1_LEIBR
Q4Q089, MTR1_LEIMAQ38AH0, MTR1_TRYB2Q4E123, MTR1_TRYCC
Q91B85, POLG_ALKVC8XPA8, POLG_BANVQ32ZE0, POLG_BUSV
P27909, POLG_DEN1BP33478, POLG_DEN1SP17763, POLG_DEN1W
P29990, POLG_DEN26P29991, POLG_DEN27P14337, POLG_DEN28
P07564, POLG_DEN2JP14340, POLG_DEN2NP12823, POLG_DEN2P
Q9WDA6, POLG_DEN2QQ99D35, POLG_DEN3CQ5UB51, POLG_DEN3I
Q6YMS3, POLG_DEN3MP27915, POLG_DEN3PQ6YMS4, POLG_DEN3S
P09866, POLG_DEN4DQ2YHF2, POLG_DEN4HQ58HT7, POLG_DEN4P
Q5UCB8, POLG_DEN4SQ2YHF0, POLG_DEN4TC8XPB2, POLG_EHV
Q32ZD7, POLG_ILHVP27395, POLG_JAEV1P19110, POLG_JAEV5
P32886, POLG_JAEVJG3FEX6, POLG_JAEVMD7RF80, POLG_KFDV
Q32ZD5, POLG_KOKVP14335, POLG_KUNJMP29837, POLG_LANVT
P22338, POLG_LIVP33515, POLG_MCFAP05769, POLG_MVEV5
Q7T6D2, POLG_OHFVQ04538, POLG_POWVLQ32ZD4, POLG_ROCV
P09732, POLG_STEVMQ01299, POLG_TBEVHP07720, POLG_TBEVS
P14336, POLG_TBEVWQ5WPU5, POLG_USUVP06935, POLG_WNV
Q9Q6P4, POLG_WNV9C5H431, POLG_WSLVP03314, POLG_YEFV1
Q6DV88, POLG_YEFVAQ6J3P1, POLG_YEFVCQ074N0, POLG_YEFVE
Q89277, POLG_YEFVFQ98803, POLG_YEFVIQ1X881, POLG_YEFVN
Q9YRV3, POLG_YEFVTQ1X880, POLG_YEFVUQ32ZE1, POLG_ZIKV
A0A024B7W1, POLG_ZIKVFA0A142I5B9, POLG_ZIKVKP0C6W1, R1AB_BC133
P0C6V9, R1AB_BC279P0C6W0, R1AB_BC512P0C6W2, R1AB_BCHK3
P0C6W3, R1AB_BCHK4P0C6W4, R1AB_BCHK5P0C6W5, R1AB_BCHK9
P0C6W6, R1AB_BCRP3P0C6W7, R1AB_CVBENP0C6W8, R1AB_CVBLU
P0C6W9, R1AB_CVBMP0C6X0, R1AB_CVBQP0C6X1, R1AB_CVH22
P0C6X2, R1AB_CVHN1P0C6X3, R1AB_CVHN2P0C6X4, R1AB_CVHN5
P0C6X5, R1AB_CVHNLP0C6X6, R1AB_CVHOCP0C6X8, R1AB_CVM2
P0C6X9, R1AB_CVMA5P0C6Y0, R1AB_CVMJHP0C6Y5, R1AB_CVPPU
Q98VG9, R1AB_FIPVP0C6Y1, R1AB_IBVBP0C6Y2, R1AB_IBVBC
P0C6Y3, R1AB_IBVMK9N7C7, R1AB_MERS1P0C6Y4, R1AB_PEDV7
P0C6X7, R1AB_SARSP0DTD1, R1AB_SARS2Q008X6, R1AB_WBV24

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