ENZYME entry: EC 2.1.1.57

Accepted Name
Methyltransferase cap1.
Alternative Name(s)
Cap1-MTase.
mRNA (nucleoside-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] <=> S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA]
Comment(s)
  • This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine.
  • This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses.
  • The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine.
  • Formerly EC 2.1.1.58.
Cross-references
BRENDA2.1.1.57
EC2PDB2.1.1.57
ExplorEnz2.1.1.57
PRIAM enzyme-specific profiles2.1.1.57
KEGG Ligand Database for Enzyme Nomenclature2.1.1.57
IUBMB Enzyme Nomenclature2.1.1.57
IntEnz2.1.1.57
MEDLINEFind literature relating to 2.1.1.57
MetaCyc2.1.1.57
UniProtKB/Swiss-Prot
D2HRF1, CMTR1_AILME;  A2VE39, CMTR1_BOVIN;  Q803R5, CMTR1_DANRE;  
Q8N1G2, CMTR1_HUMAN;  Q9DBC3, CMTR1_MOUSE;  Q5R981, CMTR1_PONAB;  
Q5U2Z5, CMTR1_RAT;  Q6GQ76, CMTR1_XENLA;  P15916, MCE_FOWPN;  
P68544, MCE_MYXVL;  P68545, MCE_MYXVU;  P19748, MCE_SHEVK;  
P23334, MCE_SWPVK;  Q76ZT1, MCE_VACCA;  P21033, MCE_VACCC;  
P07617, MCE_VACCW;  P33052, MCE_VAR67;  A8XYX2, MTR1A_CAEBR;  
Q9NAA5, MTR1_CAEEL;  Q54WR1, MTR1_DICDI;  Q9W4N2, MTR1_DROME;  
A4HQI9, MTR1_LEIBR;  Q4Q089, MTR1_LEIMA;  Q38AH0, MTR1_TRYB2;  
Q4E123, MTR1_TRYCC;  P27909, POLG_DEN1B;  P33478, POLG_DEN1S;  
P17763, POLG_DEN1W;  P29990, POLG_DEN26;  P29991, POLG_DEN27;  
P14337, POLG_DEN28;  P07564, POLG_DEN2J;  P14340, POLG_DEN2N;  
P12823, POLG_DEN2P;  Q9WDA6, POLG_DEN2Q;  Q99D35, POLG_DEN3C;  
Q5UB51, POLG_DEN3I;  Q6YMS3, POLG_DEN3M;  P27915, POLG_DEN3P;  
Q6YMS4, POLG_DEN3S;  P09866, POLG_DEN4D;  Q2YHF2, POLG_DEN4H;  
Q58HT7, POLG_DEN4P;  Q5UCB8, POLG_DEN4S;  Q2YHF0, POLG_DEN4T;  
P27395, POLG_JAEV1;  P19110, POLG_JAEV5;  P32886, POLG_JAEVJ;  
P14335, POLG_KUNJM;  P29837, POLG_LANVT;  P22338, POLG_LIV;  
P33515, POLG_MCFA;  P05769, POLG_MVEV5;  Q04538, POLG_POWVL;  
P09732, POLG_STEVM;  Q01299, POLG_TBEVH;  P07720, POLG_TBEVS;  
P14336, POLG_TBEVW;  P06935, POLG_WNV;  P03314, POLG_YEFV1;  
Q6DV88, POLG_YEFVA;  Q6J3P1, POLG_YEFVC;  Q074N0, POLG_YEFVE;  
Q89277, POLG_YEFVF;  Q98803, POLG_YEFVI;  Q1X881, POLG_YEFVN;  
Q9YRV3, POLG_YEFVT;  Q1X880, POLG_YEFVU;  Q32ZE1, POLG_ZIKV;  

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