ENZYME entry: EC 2.1.1.67

Accepted Name
Thiopurine S-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a thiopurine <=> S-adenosyl-L-homocysteine + a thiopurine S-methylether
Comment(s)
  • Also acts, more slowly, on thiopyrimidines and aromatic thiols.
  • Not identical with EC 2.1.1.9.
Cross-references
BRENDA2.1.1.67
EC2PDB2.1.1.67
ExplorEnz2.1.1.67
PRIAM enzyme-specific profiles2.1.1.67
KEGG Ligand Database for Enzyme Nomenclature2.1.1.67
IUBMB Enzyme Nomenclature2.1.1.67
IntEnz2.1.1.67
MEDLINEFind literature relating to 2.1.1.67
MetaCyc2.1.1.67
UniProtKB/Swiss-Prot
Q6F8H8, TPMT_ACIAD;  B6ENK8, TPMT_ALISL;  C1DRL5, TPMT_AZOVD;  
Q2KV81, TPMT_BORA1;  Q7WM36, TPMT_BORBR;  Q7W8H4, TPMT_BORPA;  
A9I3K3, TPMT_BORPD;  Q7VZM5, TPMT_BORPE;  Q17QQ2, TPMT_BOVIN;  
Q8HX86, TPMT_CANFA;  Q3BCR4, TPMT_CHLAE;  Q504A5, TPMT_DANRE;  
Q6EIC1, TPMT_FELCA;  Q14FX6, TPMT_FRAT1;  A0Q3W9, TPMT_FRATN;  
Q5NEH3, TPMT_FRATT;  Q5FT39, TPMT_GLUOX;  Q3BCR3, TPMT_GORGO;  
Q3BCR6, TPMT_HORSE;  P51580, TPMT_HUMAN;  Q5X154, TPMT_LEGPA;  
A5II06, TPMT_LEGPC;  Q5ZRP5, TPMT_LEGPH;  Q5WSX9, TPMT_LEGPL;  
Q3BCR5, TPMT_LYCPI;  Q3BCR9, TPMT_LYNRU;  A1U560, TPMT_MARAV;  
Q60AQ2, TPMT_METCA;  O55060, TPMT_MOUSE;  Q9QX22, TPMT_MUSSP;  
Q0ADU3, TPMT_NITEC;  Q2Y6S0, TPMT_NITMU;  Q3BCR0, TPMT_PANLE;  
Q3BCR1, TPMT_PANPR;  Q3BCR2, TPMT_PANTI;  Q3BCR8, TPMT_PANTR;  
Q6LRI5, TPMT_PHOPR;  Q5RBJ3, TPMT_PONPY;  A6V3Q8, TPMT_PSEA7;  
B7VAP9, TPMT_PSEA8;  Q02NZ5, TPMT_PSEAB;  Q9I011, TPMT_PSEAE;  
Q1ID19, TPMT_PSEE4;  Q4K8U2, TPMT_PSEF5;  C3K732, TPMT_PSEFS;  
A4XVB5, TPMT_PSEMY;  A5W759, TPMT_PSEP1;  Q3K932, TPMT_PSEPF;  
B0KUP7, TPMT_PSEPG;  Q88LQ9, TPMT_PSEPK;  B1J4W2, TPMT_PSEPW;  
O86262, TPMT_PSESJ;  Q885Q4, TPMT_PSESM;  Q4ZQC3, TPMT_PSEU2;  
Q93JT2, TPMT_PSEU5;  Q1Q8I2, TPMT_PSYCK;  Q3BCQ8, TPMT_RABIT;  
Q9Z0T0, TPMT_RAT;  A1S2Z7, TPMT_SHEAM;  B8ECC0, TPMT_SHEB2;  
A3D007, TPMT_SHEB5;  A6WSW9, TPMT_SHEB8;  A9L3X6, TPMT_SHEB9;  
Q12RU3, TPMT_SHEDO;  Q07XD8, TPMT_SHEFN;  B0TSS5, TPMT_SHEHH;  
A3QI29, TPMT_SHELP;  Q8EJ86, TPMT_SHEON;  A8H029, TPMT_SHEPA;  
A4YAM5, TPMT_SHEPC;  B8CUG6, TPMT_SHEPW;  A0KSQ0, TPMT_SHESA;  
A8G0J1, TPMT_SHESH;  Q0HMQ6, TPMT_SHESM;  Q0HR25, TPMT_SHESR;  
A1RFQ1, TPMT_SHESW;  B1KHT1, TPMT_SHEWM;  C5BIS1, TPMT_TERTT;  
A5F1V4, TPMT_VIBC3;  A7MVH9, TPMT_VIBCB;  Q9KSN0, TPMT_VIBCH;  
C3LLS2, TPMT_VIBCM;  Q5E4N9, TPMT_VIBF1;  B5FEQ9, TPMT_VIBFM;  
Q87Q54, TPMT_VIBPA;  B7VPF3, TPMT_VIBSL;  Q8DA33, TPMT_VIBVU;  
Q7MK46, TPMT_VIBVY;  Q8PMI8, TPMT_XANAC;  Q3BVI6, TPMT_XANC5;  
Q4UST1, TPMT_XANC8;  Q8PAT3, TPMT_XANCP;  A7IIX3, TPMT_XANP2;  
Q6C6X6, TPMT_YARLI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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