ENZYME

ENZYME entry: EC 2.1.1.69

Accepted Name

5-hydroxyfuranocoumarin 5-O-methyltransferase.

Alternative Name(s)

Bergaptol 5-O-methyltransferase.

Bergaptol methyltransferase.

Bergaptol O-methyltransferase.

BMT.

Furanocoumarin 5-methyltransferase.

Furanocoumarin 5-O-methyltransferase.

Reaction catalysed

S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin
S-adenosyl-L-methionine + bergaptol <=> S-adenosyl-L-homocysteine + bergapten

Comment(s)

Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
Methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols; caffeate, 5-hydroxyferulate and daphnetin are not substrates.
Cu(2+), Zn(2+) and Co(2+) cause enzyme inhibition.
See also EC 2.1.1.70.
Formerly EC 2.1.1.92.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature