ID 2.1.1.89 DE Tetrahydrocolumbamine 2-O-methyltransferase. CA S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl- CA L-homocysteine + tetrahydropalmatine. CC -!- Involved in the biosynthesis of the berberine alkaloids. DR Q8H9A8, COOMT_COPJA; //