ID 2.1.1.89 DE tetrahydrocolumbamine 2-O-methyltransferase. CA (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)- CA tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine. CC -!- Involved in the biosynthesis of the berberine alkaloids. DR Q8H9A8, COOMT_COPJA; I3V6A7, SOMT1_PAPSO; //