ENZYME entry: EC 2.1.1.n8

Accepted Name
Small RNA 2'-O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide
Comment(s)
  • Adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs).
  • This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation.
  • Can methylates 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs).
Cross-references
UniProtKB/Swiss-Prot
Q9C5Q8, HEN1_ARATH;  E1BVR9, HENMT_CHICK;  Q568P9, HENMT_DANRE;  
Q7K175, HENMT_DROME;  Q5T8I9, HENMT_HUMAN;  Q4R3W5, HENMT_MACFA;  
Q8CAE2, HENMT_MOUSE;  Q32PY6, HENMT_RAT;  Q9UST9, HENMT_SCHPO;  
Q230X8, HENMT_TETTS;  C0IN03, HENMT_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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