ENZYME entry: EC 2.2.1.10

Accepted Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.
Alternative Name(s)
ADH synthase.
Reaction catalysed
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate <=> 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3-dioxopropylaldehyde phosphate
Comment(s)
  • The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate.
  • Formerly EC 4.1.2.n5.
Cross-references
BRENDA2.2.1.10
EC2PDB2.2.1.10
ExplorEnz2.2.1.10
PRIAM enzyme-specific profiles2.2.1.10
KEGG Ligand Database for Enzyme Nomenclature2.2.1.10
IUBMB Enzyme Nomenclature2.2.1.10
IntEnz2.2.1.10
MEDLINEFind literature relating to 2.2.1.10
MetaCyc2.2.1.10
UniProtKB/Swiss-Prot
O30009, ADHS1_ARCFU;  O30128, ADHS2_ARCFU;  O67506, ADHS_AQUAE;  
Q9HSB8, ADHS_HALSA;  A6UTT2, ADHS_META3;  Q57843, ADHS_METJA;  
A4FYB3, ADHS_METM5;  A9A799, ADHS_METM6;  A6VJZ0, ADHS_METM7;  
Q6LZE3, ADHS_METMP;  O26679, ADHS_METTH;  A6USC8, ADHS_METVS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-