Expasy logo

ENZYME

ENZYME entry: EC 2.2.1.12

Accepted Name
3-acetyloctanal synthase
Reaction catalysed
(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2
Comment(s)
  • The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin.
  • The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction.
  • In vitro the enzyme can act on a number of alpha,beta-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyze both 1-2 and 1-4 carboligations depending on the substrate.
Cross-references
BRENDA2.2.1.12
EC2PDB2.2.1.12
ExplorEnz2.2.1.12
PRIAM enzyme-specific profiles2.2.1.12
KEGG Ligand Database for Enzyme Nomenclature2.2.1.12
IUBMB Enzyme Nomenclature2.2.1.12
IntEnz2.2.1.12
MEDLINEFind literature relating to 2.2.1.12
MetaCyc2.2.1.12
Rhea expert-curated reactions2.2.1.12
UniProtKB/Swiss-Prot
Q5W251, PIGD_SERMAQ5W268, PIGD_SERS3

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-