ENZYME entry: EC 2.2.1.5
| Accepted Name |
|---|
| 2-hydroxy-3-oxoadipate synthase.
|
| Alternative Name(s) |
|---|
| 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating). |
| 2-hydroxy-3-oxoadipate synthetase. |
| Alpha-ketoglutaric-glyoxylic carboligase. |
| Oxoglutarate: glyoxylate carboligase. |
| Reaction catalysed |
|---|
| 2-oxoglutarate + glyoxylate <=> 2-hydroxy-3-oxoadipate + CO(2) |
| Cofactor(s) |
|---|
| Thiamine diphosphate.
|
| Comment(s) |
|---|
- The product decarboxylates to 5-hydroxy-4-oxopentanoate.
- The enzyme can decarboxylate 2-oxoglutarate.
- Acetaldehyde can replace glyoxylate.
- Formerly EC 4.1.3.15.
|
| Cross-references |
|---|
| BRENDA | 2.2.1.5 |
| EC2PDB | 2.2.1.5 |
| ExplorEnz | 2.2.1.5 |
| PRIAM enzyme-specific profiles | 2.2.1.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.2.1.5 |
| IUBMB Enzyme Nomenclature | 2.2.1.5 |
| IntEnz | 2.2.1.5 |
| MEDLINE | Find literature relating to 2.2.1.5 |
| MetaCyc | 2.2.1.5 |
| UniProtKB/Swiss-Prot |
| Q7U0A6, KGD_MYCBO; | A1KI36, KGD_MYCBP; | Q9CC97, KGD_MYCLE; |
| Q73WX4, KGD_MYCPA; | A0R2B1, KGD_MYCS2; | A3Q3N5, KGD_MYCSJ; |
| A1UK81, KGD_MYCSK; | Q1B4V6, KGD_MYCSS; | A5U1U6, KGD_MYCTA; |
| O50463, KGD_MYCTU; | A0PVU7, KGD_MYCUA; | A1TDK2, KGD_MYCVP; |
|
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