ENZYME entry: EC 2.2.1.7

Accepted Name
1-deoxy-D-xylulose-5-phosphate synthase.
Alternative Name(s)
1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating).
1-deoxyxylulose-5-phosphate synthase.
DXP-synthase.
Reaction catalysed
Pyruvate + D-glyceraldehyde 3-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
  • Formerly EC 4.1.3.37.
Cross-references
PROSITEPDOC00635
BRENDA2.2.1.7
EC2PDB2.2.1.7
ExplorEnz2.2.1.7
PRIAM enzyme-specific profiles2.2.1.7
KEGG Ligand Database for Enzyme Nomenclature2.2.1.7
IUBMB Enzyme Nomenclature2.2.1.7
IntEnz2.2.1.7
MEDLINEFind literature relating to 2.2.1.7
MetaCyc2.2.1.7
UniProtKB/Swiss-Prot
Q39UB1, DXS1_GEOMG;  Q74FC3, DXS1_GEOSL;  Q28WA7, DXS1_JANSC;  
Q9F1V2, DXS1_KITGR;  O22567, DXS1_ORYSJ;  Q2RYD6, DXS1_RHORT;  
Q3J1A8, DXS1_RHOS4;  Q16DV7, DXS1_ROSDO;  Q82ML4, DXS1_STRAW;  
Q9X7W3, DXS1_STRCO;  Q5NN52, DXS1_ZYMMO;  Q39RT4, DXS2_GEOMG;  
Q74CB0, DXS2_GEOSL;  Q28W25, DXS2_JANSC;  Q8VUR8, DXS2_KITGR;  
Q6YU51, DXS2_ORYSJ;  Q2RR29, DXS2_RHORT;  Q3IYR6, DXS2_RHOS4;  
Q16CP0, DXS2_ROSDO;  Q82KW8, DXS2_STRAW;  Q8CJP7, DXS2_STRCO;  
Q5NM38, DXS2_ZYMMO;  B0C8J3, DXS_ACAM1;  A1TNR1, DXS_ACIAC;  
Q6F7N5, DXS_ACIAD;  B0VQB8, DXS_ACIBS;  B0V710, DXS_ACIBY;  
C1F3C4, DXS_ACIC5;  B9MEU8, DXS_ACIET;  A1W4U9, DXS_ACISJ;  
A3MYS9, DXS_ACTP2;  B3H050, DXS_ACTP7;  B0BSL0, DXS_ACTPJ;  
A0KNF9, DXS_AERHH;  A4SJP9, DXS_AERS4;  Q8UHD7, DXS_AGRFC;  
B9JAL7, DXS_AGRRK;  B9JSL2, DXS_AGRVS;  Q0VMI4, DXS_ALCBS;  
B6EIA7, DXS_ALISL;  Q0A8V7, DXS_ALKEH;  A8MFI7, DXS_ALKOO;  
B4RVY8, DXS_ALTMD;  B8JFY1, DXS_ANAD2;  Q2IPZ2, DXS_ANADE;  
A7H9E8, DXS_ANADF;  B4UHF5, DXS_ANASK;  Q3M4F6, DXS_ANAVT;  
O67036, DXS_AQUAE;  Q38854, DXS_ARATH;  A8EWN0, DXS_ARCB4;  
Q5P228, DXS_AROAE;  A1R5N7, DXS_ARTAT;  A0JVG9, DXS_ARTS2;  
A8IBS1, DXS_AZOC5;  B6YRV5, DXS_AZOPC;  A1K4R0, DXS_AZOSB;  
C3P7V6, DXS_BACAA;  C3LJV1, DXS_BACAC;  Q81M54, DXS_BACAN;  
B7JM28, DXS_BACC0;  Q731B7, DXS_BACC1;  B7IXG8, DXS_BACC2;  
B7HB48, DXS_BACC4;  B7HNU0, DXS_BACC7;  A7GSJ5, DXS_BACCN;  
Q818R9, DXS_BACCR;  Q635A7, DXS_BACCZ;  Q5LH44, DXS_BACFN;  
Q64Y02, DXS_BACFR;  Q9K971, DXS_BACHD;  Q6HDY8, DXS_BACHK;  
Q65HJ2, DXS_BACLD;  A7Z6J5, DXS_BACMF;  A8FF11, DXS_BACP2;  
Q5WF63, DXS_BACSK;  P54523, DXS_BACSU;  Q8A0C2, DXS_BACTN;  
A6L175, DXS_BACV8;  A9VGD1, DXS_BACWK;  A1URW6, DXS_BARBK;  
Q6G4D1, DXS_BARHE;  Q6G0D4, DXS_BARQU;  A9IQP2, DXS_BART1;  
Q1LTI9, DXS_BAUCH;  B2IDK3, DXS_BEII9;  Q7VRH9, DXS_BLOFL;  
Q493G7, DXS_BLOPB;  Q2KZ15, DXS_BORA1;  Q7WL37, DXS_BORBR;  
Q7W7Q0, DXS_BORPA;  A9ITB0, DXS_BORPD;  Q7VV87, DXS_BORPE;  
Q89RW1, DXS_BRADU;  A5EEQ0, DXS_BRASB;  A4YQ36, DXS_BRASO;  
C0ZC10, DXS_BREBN;  B2S9T6, DXS_BRUA1;  Q2YMF0, DXS_BRUA2;  
Q57ET1, DXS_BRUAB;  A9M8W0, DXS_BRUC2;  C0RHE3, DXS_BRUMB;  
Q8YFM2, DXS_BRUME;  A5VP09, DXS_BRUO2;  B0CKC0, DXS_BRUSI;  
Q8G292, DXS_BRUSU;  B8D9P1, DXS_BUCA5;  P57536, DXS_BUCAI;  
Q8K9A1, DXS_BUCAP;  B8D7Z3, DXS_BUCAT;  B1Z1G2, DXS_BURA4;  
Q1BLY7, DXS_BURCA;  B1K3S9, DXS_BURCC;  A0AYZ0, DXS_BURCH;  
B4EN29, DXS_BURCJ;  Q0BAL8, DXS_BURCM;  Q393P4, DXS_BURL3;  
Q62DU1, DXS_BURMA;  A3P7W4, DXS_BURP0;  Q3JKA3, DXS_BURP1;  
A3NMF6, DXS_BURP6;  B2JP68, DXS_BURP8;  Q63JF4, DXS_BURPS;  
Q2T7N5, DXS_BURTA;  Q13RX1, DXS_BURXL;  Q8RAC5, DXS_CALS4;  
A0RMN5, DXS_CAMFF;  A7I2V7, DXS_CAMHC;  A8FKB0, DXS_CAMJ8;  
A7H552, DXS_CAMJD;  Q9PIH8, DXS_CAMJE;  A1VY40, DXS_CAMJJ;  
Q5HWF0, DXS_CAMJR;  O78328, DXS_CAPAN;  Q3AAN0, DXS_CARHZ;  
B8GXC4, DXS_CAUCN;  Q9A6M5, DXS_CAUCR;  B0T3X7, DXS_CAUSK;  
B3PF22, DXS_CELJU;  Q11KE0, DXS_CHESB;  Q5L6H4, DXS_CHLAB;  
Q823V1, DXS_CHLCV;  Q253R7, DXS_CHLFF;  Q3B5P3, DXS_CHLL7;  
Q9PK62, DXS_CHLMU;  A4SDG1, DXS_CHLPM;  Q9Z6J9, DXS_CHLPN;  
B0B7P9, DXS_CHLT2;  Q3KM28, DXS_CHLTA;  B0BBW4, DXS_CHLTB;  
Q8KFI9, DXS_CHLTE;  O84335, DXS_CHLTR;  Q1R1E5, DXS_CHRSD;  
Q7NUK5, DXS_CHRVO;  A8AK34, DXS_CITK8;  B0RC26, DXS_CLAMS;  
Q97HD5, DXS_CLOAB;  A6LU48, DXS_CLOB8;  B2V4R3, DXS_CLOBA;  
B2TRM5, DXS_CLOBB;  B9E104, DXS_CLOK1;  A5N7J2, DXS_CLOK5;  
A0Q0A4, DXS_CLONN;  Q0TPD8, DXS_CLOP1;  Q8XJE1, DXS_CLOPE;  
A9KMB8, DXS_CLOPH;  Q0SS05, DXS_CLOPS;  Q894H0, DXS_CLOTE;  
Q487D3, DXS_COLP3;  Q6NGV3, DXS_CORDI;  Q8FPI2, DXS_COREF;  
A4QEQ9, DXS_CORGB;  Q8NPB2, DXS_CORGL;  Q4JVB5, DXS_CORJK;  
A7MFG0, DXS_CROS8;  Q1LK34, DXS_CUPMC;  Q0K860, DXS_CUPNH;  
Q474C2, DXS_CUPPJ;  B3R5H4, DXS_CUPTR;  B1WWM7, DXS_CYAA5;  
B8HWL8, DXS_CYAP4;  B7KAF7, DXS_CYAP7;  B7JVJ6, DXS_CYAP8;  
Q11NY7, DXS_CYTH3;  Q47BJ0, DXS_DECAR;  Q3Z8G9, DXS_DEHM1;  
A5FRB9, DXS_DEHMB;  Q3ZXC2, DXS_DEHMC;  Q1IZP0, DXS_DEIGD;  
Q9RUB5, DXS_DEIRA;  Q30Z99, DXS_DESAG;  B1I3J6, DXS_DESAP;  
B8FQ45, DXS_DESHD;  Q24V05, DXS_DESHY;  Q6AJQ1, DXS_DESPS;  
Q72CD3, DXS_DESVH;  A1VE69, DXS_DESVV;  B5YE06, DXS_DICT6;  
B8E247, DXS_DICTD;  A7ZIH3, DXS_ECO24;  B7UJP3, DXS_ECO27;  
B7MD78, DXS_ECO45;  B7L654, DXS_ECO55;  Q8XE76, DXS_ECO57;  
B5Z3S5, DXS_ECO5E;  B7NJ77, DXS_ECO7I;  B7MQD5, DXS_ECO81;  
B7M3Q9, DXS_ECO8A;  C4ZTH7, DXS_ECOBW;  B1XF08, DXS_ECODH;  
A7ZX72, DXS_ECOHS;  A1A890, DXS_ECOK1;  Q0TKM1, DXS_ECOL5;  
Q8FKB9, DXS_ECOL6;  B1J029, DXS_ECOLC;  P77488, DXS_ECOLI;  
B7N8X3, DXS_ECOLU;  B6HZM1, DXS_ECOSE;  B1LJH0, DXS_ECOSM;  
Q1RFC0, DXS_ECOUT;  C5BCH9, DXS_EDWI9;  A4W791, DXS_ENT38;  
B2VHS3, DXS_ERWT9;  Q2N6U5, DXS_ERYLH;  B7LMG7, DXS_ESCF3;  
B1YLQ5, DXS_EXIS2;  B0U0B3, DXS_FRAP2;  Q2JDD9, DXS_FRASC;  
A8L0K9, DXS_FRASN;  Q14HJ1, DXS_FRAT1;  A7NCA4, DXS_FRATF;  
Q2A3D3, DXS_FRATH;  B2SGK5, DXS_FRATM;  A0Q6B9, DXS_FRATN;  
Q0BLU9, DXS_FRATO;  Q5NG39, DXS_FRATT;  A4IXW5, DXS_FRATW;  
Q8R639, DXS_FUSNN;  Q75TB7, DXS_GEOKA;  C5D467, DXS_GEOSW;  
A4IQR7, DXS_GEOTN;  Q7NP63, DXS_GLOVI;  Q5FUB1, DXS_GLUOX;  
Q7VNP7, DXS_HAEDU;  Q4QKG6, DXS_HAEI8;  A5UC51, DXS_HAEIE;  
A5UEV6, DXS_HAEIG;  P45205, DXS_HAEIN;  B8F3A4, DXS_HAEPS;  
Q0I3G1, DXS_HAES1;  Q2SA08, DXS_HAHCH;  B8D2I3, DXS_HALOH;  
C4K6M7, DXS_HAMD5;  Q7VIJ7, DXS_HELHP;  B0TEJ5, DXS_HELMI;  
B5ZAB7, DXS_HELPG;  Q1CUF6, DXS_HELPH;  Q9ZM94, DXS_HELPJ;  
O25121, DXS_HELPY;  B0UUA4, DXS_HISS2;  Q0C154, DXS_HYPNA;  
Q5QVE8, DXS_IDILO;  B5Y0X1, DXS_KLEP3;  A6T5F3, DXS_KLEP7;  
B2GJ56, DXS_KOCRD;  C1DAW8, DXS_LARHH;  Q1MRB3, DXS_LAWIP;  
Q6AFD5, DXS_LEIXX;  Q04U59, DXS_LEPBJ;  Q053M2, DXS_LEPBL;  
B1Y2X5, DXS_LEPCP;  Q72U01, DXS_LEPIC;  Q8F153, DXS_LEPIN;  
Q92BZ0, DXS_LISIN;  C1L2S1, DXS_LISMC;  Q71ZV7, DXS_LISMF;  
Q8Y7C1, DXS_LISMO;  A0AIG6, DXS_LISW6;  B1HRX4, DXS_LYSSC;  
B9E6Q6, DXS_MACCJ;  A0L6H3, DXS_MAGMM;  Q2W367, DXS_MAGSA;  
Q65TP4, DXS_MANSM;  Q0ARE5, DXS_MARMM;  A6VUE5, DXS_MARMS;  
Q60AN1, DXS_METCA;  Q1GZD7, DXS_METFK;  B3DW88, DXS_METI4;  
A2SJ46, DXS_METPP;  B0JL88, DXS_MICAN;  Q2RIB9, DXS_MOOTA;  
A0QIL6, DXS_MYCA1;  B1MCU7, DXS_MYCA9;  P0A555, DXS_MYCBO;  
A1KM20, DXS_MYCBP;  C1AFE1, DXS_MYCBT;  A4TCS5, DXS_MYCGI;  
B8ZQW9, DXS_MYCLB;  Q50000, DXS_MYCLE;  Q73W57, DXS_MYCPA;  
Q8EWX7, DXS_MYCPE;  A0QW19, DXS_MYCS2;  A3PYK6, DXS_MYCSJ;  
A1UF44, DXS_MYCSK;  Q1B9W8, DXS_MYCSS;  A5U634, DXS_MYCTA;  
P9WNS2, DXS_MYCTO;  P9WNS3, DXS_MYCTU;  A0PT40, DXS_MYCUA;  
A1T7Z0, DXS_MYCVP;  Q1D3G4, DXS_MYXXD;  B2A526, DXS_NATTJ;  
Q5FAI2, DXS_NEIG1;  B4RNW6, DXS_NEIG2;  A9M1G3, DXS_NEIM0;  
Q9JW13, DXS_NEIMA;  Q9JXV7, DXS_NEIMB;  A1KS32, DXS_NEIMF;  
Q0AFY6, DXS_NITEC;  Q82VD3, DXS_NITEU;  Q1QQ40, DXS_NITHX;  
Q2YCH7, DXS_NITMU;  Q3JAD1, DXS_NITOC;  A6Q1Z6, DXS_NITSB;  
Q3SUZ1, DXS_NITWN;  Q5YTA2, DXS_NOCFA;  A1SKM6, DXS_NOCSJ;  
B2J5P1, DXS_NOSP7;  Q8YZ80, DXS_NOSS1;  Q2GC13, DXS_NOVAD;  
A6WWC4, DXS_OCHA4;  A6LFB9, DXS_PARD8;  Q6MDK6, DXS_PARUW;  
P57848, DXS_PASMU;  Q6D844, DXS_PECAS;  C6DB37, DXS_PECCP;  
Q3A3Z6, DXS_PELCD;  A5D2Z6, DXS_PELTS;  Q4FN07, DXS_PELUB;  
Q18B68, DXS_PEPD6;  B4RGW0, DXS_PHEZH;  Q7N0J7, DXS_PHOLL;  
Q6LU07, DXS_PHOPR;  A1VMD7, DXS_POLNA;  Q12CQ9, DXS_POLSJ;  
B2RMK4, DXS_PORG3;  Q7MSZ3, DXS_PORGI;  Q6A8V3, DXS_PROAC;  
A3PCV0, DXS_PROM0;  A2C220, DXS_PROM1;  A8G4R9, DXS_PROM2;  
A2C9X1, DXS_PROM3;  A9BAC1, DXS_PROM4;  A2BWN6, DXS_PROM5;  
Q31AZ2, DXS_PROM9;  Q7VC14, DXS_PROMA;  B4EU31, DXS_PROMH;  
Q7V7Q3, DXS_PROMM;  Q7V1G6, DXS_PROMP;  A2BR27, DXS_PROMS;  
Q46L36, DXS_PROMT;  Q48NX0, DXS_PSE14;  Q15W93, DXS_PSEA6;  
A6V058, DXS_PSEA7;  B7V7R4, DXS_PSEA8;  Q02SL1, DXS_PSEAB;  
Q9KGU7, DXS_PSEAE;  B8HH36, DXS_PSECP;  Q1IFL1, DXS_PSEE4;  
Q4K5A5, DXS_PSEF5;  C3K2R1, DXS_PSEFS;  Q3II09, DXS_PSEHT;  
A4XZ25, DXS_PSEMY;  A5VXW9, DXS_PSEP1;  Q3K660, DXS_PSEPF;  
B0KL79, DXS_PSEPG;  Q88QG7, DXS_PSEPK;  B1J3G4, DXS_PSEPW;  
Q889Q1, DXS_PSESM;  Q4ZYU8, DXS_PSEU2;  A4VQS8, DXS_PSEU5;  
Q4FV64, DXS_PSYA2;  Q1QE74, DXS_PSYCK;  A1SWW6, DXS_PSYIN;  
B2U930, DXS_RALPJ;  Q8XX95, DXS_RALSO;  A9WRA9, DXS_RENSM;  
B3PS68, DXS_RHIE6;  Q2KBR2, DXS_RHIEC;  Q1MKN4, DXS_RHIL3;  
Q985Y3, DXS_RHILO;  B5ZS68, DXS_RHILW;  Q92RJ1, DXS_RHIME;  
Q7UWB7, DXS_RHOBA;  P26242, DXS_RHOCA;  B6IRB5, DXS_RHOCS;  
C0ZYV9, DXS_RHOE4;  Q21UG7, DXS_RHOFT;  Q0S1H1, DXS_RHOJR;  
Q2IRL7, DXS_RHOP2;  Q07SR3, DXS_RHOP5;  Q6NB76, DXS_RHOPA;  
Q21A74, DXS_RHOPB;  Q130G7, DXS_RHOPS;  B3QFY7, DXS_RHOPT;  
Q5LX42, DXS_RUEPO;  Q1GCG4, DXS_RUEST;  Q21F93, DXS_SACD2;  
A4FAQ5, DXS_SACEN;  B5EXG3, DXS_SALA4;  A9MM42, DXS_SALAR;  
Q57SE2, DXS_SALCH;  B5FKS7, DXS_SALDC;  B5QTH0, DXS_SALEP;  
B5R6S3, DXS_SALG2;  B4T8R3, DXS_SALHS;  B4SWR4, DXS_SALNS;  
Q5PFR6, DXS_SALPA;  A9MX09, DXS_SALPB;  C0Q7U7, DXS_SALPC;  
B5BDB0, DXS_SALPK;  B4TMA2, DXS_SALSV;  Q8Z8X3, DXS_SALTI;  
Q8ZRD1, DXS_SALTY;  A8GAP2, DXS_SERP5;  A1S8D4, DXS_SHEAM;  
B8EAU7, DXS_SHEB2;  A3D2B2, DXS_SHEB5;  A6WL04, DXS_SHEB8;  
A9KTL5, DXS_SHEB9;  Q12L26, DXS_SHEDO;  Q07ZD4, DXS_SHEFN;  
B0TQ36, DXS_SHEHH;  A3QGN9, DXS_SHELP;  Q8EGR9, DXS_SHEON;  
A8H6X1, DXS_SHEPA;  A4Y4X0, DXS_SHEPC;  B8CS19, DXS_SHEPW;  
A0KZA9, DXS_SHESA;  A8FYL0, DXS_SHESH;  Q0HGL5, DXS_SHESM;  
Q0HSW6, DXS_SHESR;  A1RLV3, DXS_SHESW;  B1KQY8, DXS_SHEWM;  
B2U4M3, DXS_SHIB3;  Q325I1, DXS_SHIBS;  Q32JH8, DXS_SHIDS;  
Q83SG2, DXS_SHIFL;  Q3Z4Y9, DXS_SHISS;  Q2NV94, DXS_SODGM;  
Q1GQK9, DXS_SPHAL;  A5V6A9, DXS_SPHWW;  Q9RBN6, DXS_STRC1;  
B1VWJ8, DXS_STRGG;  B2FN57, DXS_STRMK;  Q30TC5, DXS_SULDN;  
Q67NB6, DXS_SYMTH;  Q2LUA7, DXS_SYNAS;  Q8GAA0, DXS_SYNE7;  
Q2JTX2, DXS_SYNJA;  Q2JK64, DXS_SYNJB;  B1XKC5, DXS_SYNP2;  
Q9R6S7, DXS_SYNP6;  A5GL34, DXS_SYNPW;  Q7U6P6, DXS_SYNPX;  
A5GTT4, DXS_SYNR3;  Q0IAA6, DXS_SYNS3;  Q3AXZ4, DXS_SYNS9;  
Q3AJP8, DXS_SYNSC;  Q0AZE2, DXS_SYNWW;  P73067, DXS_SYNY3;  
Q8DL74, DXS_THEEB;  Q47NL9, DXS_THEFY;  Q9X291, DXS_THEMA;  
A5ILK2, DXS_THEP1;  B9L1L6, DXS_THERP;  B1LAQ3, DXS_THESQ;  
Q72H81, DXS_THET2;  Q5SMD7, DXS_THET8;  Q3SKF1, DXS_THIDA;  
B8GN62, DXS_THISH;  Q73LF4, DXS_TREDE;  O83796, DXS_TREPA;  
B2S462, DXS_TREPS;  Q10ZY2, DXS_TRIEI;  Q83I20, DXS_TROW8;  
Q83G46, DXS_TROWT;  A1WN06, DXS_VEREI;  A5F331, DXS_VIBC3;  
A7MYC6, DXS_VIBCB;  Q9KTL3, DXS_VIBCH;  C3LTD9, DXS_VIBCM;  
Q5E6Z0, DXS_VIBF1;  B5FBG6, DXS_VIBFM;  Q87RU0, DXS_VIBPA;  
B7VJA1, DXS_VIBTL;  Q8DFA3, DXS_VIBVU;  Q7MN49, DXS_VIBVY;  
Q8D357, DXS_WIGBR;  Q7M7Z0, DXS_WOLSU;  Q8PJG7, DXS_XANAC;  
Q3BRW8, DXS_XANC5;  Q4UW29, DXS_XANC8;  Q8P815, DXS_XANCP;  
Q2P472, DXS_XANOM;  B2SQV8, DXS_XANOP;  Q5H1A0, DXS_XANOR;  
A7IPK6, DXS_XANP2;  B2I607, DXS_XYLF2;  Q9PB95, DXS_XYLFA;  
B0U3E1, DXS_XYLFM;  Q87C03, DXS_XYLFT;  A1JNR7, DXS_YERE8;  
A7FLE4, DXS_YERP3;  Q1C4I9, DXS_YERPA;  B2K6T7, DXS_YERPB;  
Q8ZC45, DXS_YERPE;  A9QZS3, DXS_YERPG;  Q1CL87, DXS_YERPN;  
A4TPG2, DXS_YERPP;  Q66DV4, DXS_YERPS;  B1JID8, DXS_YERPY;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-