Expasy logo

ENZYME

ENZYME entry: EC 2.3.1.135

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.135
Accepted Name
phosphatidylcholine--retinol O-acyltransferase
Alternative Name(s)
lecithin retinol acyl transferase
lecithin-retinol acyltransferase
lecithin--retinol acyltransferase
retinyl ester synthase
Reaction catalysed
all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
Comment(s)
  • A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.
  • Can also esterify 11-cis-retinol.
Cross-references
Rhea expert-curated reactions2.3.1.135
ExplorEnz2.3.1.135
IUBMB Enzyme Nomenclature2.3.1.135
UniProtKB/Swiss-Prot
Q9BGL2, LRAT_BOVINO95237, LRAT_HUMANQ9JI60, LRAT_MOUSE
Q9JI61, LRAT_RAT
BRENDA2.3.1.135
MetaCyc2.3.1.135
KEGG Ligand Database for Enzyme Nomenclature2.3.1.135
EC2PDB2.3.1.135
MEDLINEFind literature relating to 2.3.1.135

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-