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ENZYME

ENZYME entry: EC 2.3.1.135

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.135
Accepted Name
phosphatidylcholine--retinol O-acyltransferase
Alternative Name(s)
lecithin retinol acyl transferase
lecithin-retinol acyltransferase
lecithin--retinol acyltransferase
retinyl ester synthase
Reaction catalysed
all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
Comment(s)
  • A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.
  • Can also esterify 11-cis-retinol.
Cross-references
BRENDA2.3.1.135
EC2PDB2.3.1.135
ExplorEnz2.3.1.135
KEGG Ligand Database for Enzyme Nomenclature2.3.1.135
IUBMB Enzyme Nomenclature2.3.1.135
MEDLINEFind literature relating to 2.3.1.135
MetaCyc2.3.1.135
Rhea expert-curated reactions2.3.1.135
UniProtKB/Swiss-Prot
Q9BGL2, LRAT_BOVINO95237, LRAT_HUMANQ9JI60, LRAT_MOUSE
Q9JI61, LRAT_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-