ENZYME entry: EC 2.3.1.156
| Accepted Name |
|---|
| Phloroisovalerophenone synthase.
|
| Alternative Name(s) |
|---|
| 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase. |
| Valerophenone synthase. |
| Reaction catalysed |
|---|
| Isovaleryl-CoA + 3 malonyl-CoA <=> 4 CoA + 3 CO(2) + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one |
| Comment(s) |
|---|
- Closely related to EC 2.3.1.74.
- The product, 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one,
is phloroisovalerophenone.
- Also acts on isobutyryl-CoA as substrate to give
phlorisobutyrophenone.
- The products are intermediates in the biosynthesis of the bitter
(alpha) acids in hops (Humulus lupulus).
|
| Cross-references |
|---|
| PROSITE | PDOC00403 |
| BRENDA | 2.3.1.156 |
| EC2PDB | 2.3.1.156 |
| ExplorEnz | 2.3.1.156 |
| PRIAM enzyme-specific profiles | 2.3.1.156 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.156 |
| IUBMB Enzyme Nomenclature | 2.3.1.156 |
| IntEnz | 2.3.1.156 |
| MEDLINE | Find literature relating to 2.3.1.156 |
| MetaCyc | 2.3.1.156 |
| UniProtKB/Swiss-Prot |
|
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