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ENZYME entry: EC 2.3.1.162

Accepted Name
Taxadien-5-alpha-ol O-acetyltransferase.
Alternative Name(s)
Taxa-4(20),11(12)-dien-5-alpha-ol O-acetyltransferase.
Taxadienol acetyltransferase.
Reaction catalysed
Acetyl-CoA + taxa-4(20),11-dien-5-alpha-ol <=> CoA + taxa-4(20),11-dien-5-alpha-yl acetate
Comment(s)
This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
Cross-references
BRENDA2.3.1.162
EC2PDB2.3.1.162
ExplorEnz2.3.1.162
PRIAM enzyme-specific profiles2.3.1.162
KEGG Ligand Database for Enzyme Nomenclature2.3.1.162
IUBMB Enzyme Nomenclature2.3.1.162
IntEnz2.3.1.162
MEDLINEFind literature relating to 2.3.1.162
MetaCyc2.3.1.162
UniProtKB/Swiss-Prot
Q9M6F0, T5AT_TAXCU;  Q8S9G6, T5AT_TAXWC;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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