ENZYME entry: EC 2.3.1.182

Accepted Name
(R)-citramalate synthase.
Reaction catalysed
Acetyl-CoA + pyruvate + H(2)O <=> CoA + (2R)-2-hydroxy-2-methylbutanedioate
Comment(s)
  • Involved in a novel pyruvate pathway for isoleucine biosynthesis that is found mainly in archaea.
  • Can be inhibited by isoleucine, the end-product of the pathway, but not by leucine.
  • Highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate.
Cross-references
BRENDA2.3.1.182
EC2PDB2.3.1.182
ExplorEnz2.3.1.182
PRIAM enzyme-specific profiles2.3.1.182
KEGG Ligand Database for Enzyme Nomenclature2.3.1.182
IUBMB Enzyme Nomenclature2.3.1.182
IntEnz2.3.1.182
MEDLINEFind literature relating to 2.3.1.182
MetaCyc2.3.1.182
UniProtKB/Swiss-Prot
O66682, CIMA_AQUAE;  O29305, CIMA_ARCFU;  Q74C76, CIMA_GEOSL;  
Q8TJJ1, CIMA_METAC;  Q58787, CIMA_METJA;  Q8TYM1, CIMA_METKA;  
P58966, CIMA_METMA;  A3CUF2, CIMA_METMJ;  B8GEI1, CIMA_METPE;  
O26819, CIMA_METTH;  O86511, CIMA_STRCO;  P74269, CIMA_SYNY3;  
Q9WZ22, CIMA_THEMA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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