ENZYME entry: EC 2.3.1.182

Accepted Name
(R)-citramalate synthase.
Reaction catalysed
Acetyl-CoA + pyruvate + H(2)O <=> CoA + (2R)-2-hydroxy-2-methylbutanedioate
Comment(s)
Involved in a novel pyruvate pathway for isoleucine biosynthesis that is found mainly in archaea. Can be inhibited by isoleucine, the end-product of the pathway, but not by leucine. Highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate.
Cross-references
BRENDA	2.3.1.182
EC2PDB	2.3.1.182
ExplorEnz	2.3.1.182
PRIAM enzyme-specific profiles	2.3.1.182
KEGG Ligand Database for Enzyme Nomenclature	2.3.1.182
IUBMB Enzyme Nomenclature	2.3.1.182
IntEnz	2.3.1.182
MEDLINE	Find literature relating to 2.3.1.182
MetaCyc	2.3.1.182
UniProtKB/Swiss-Prot	O29305, CIMA_ARCFU;   Q8TJJ1, CIMA_METAC;   Q58787, CIMA_METJA;   Q8TYM1, CIMA_METKA;   P58966, CIMA_METMA;   A3CUF2, CIMA_METMJ;   B8GEI1, CIMA_METPE;   O26819, CIMA_METTH;

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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