ENZYME entry: EC 2.3.1.189

Accepted Name
Mycothiol synthase.
Reaction catalysed
Desacetylmycothiol + acetyl-CoA <=> CoA + mycothiol
Comment(s)
  • This enzyme catalyzes the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium.
  • The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs).
  • The enzyme has been purified from Mycobacterium tuberculosis H37Rv.
  • Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate.
Cross-references
PROSITEPDOC51186
BRENDA2.3.1.189
EC2PDB2.3.1.189
ExplorEnz2.3.1.189
PRIAM enzyme-specific profiles2.3.1.189
KEGG Ligand Database for Enzyme Nomenclature2.3.1.189
IUBMB Enzyme Nomenclature2.3.1.189
IntEnz2.3.1.189
MEDLINEFind literature relating to 2.3.1.189
MetaCyc2.3.1.189
UniProtKB/Swiss-Prot
A0LWI8, MSHD_ACIC1;  C7M077, MSHD_ACIFD;  C6WPR7, MSHD_ACTMD;  
Q5EDG0, MSHD_AMYMD;  A0JZC2, MSHD_ARTS2;  C5C246, MSHD_BEUC1;  
C7MGB3, MSHD_BRAFD;  C7QKH8, MSHD_CATAD;  D5UJR1, MSHD_CELFN;  
A5CTZ8, MSHD_CLAM3;  B0RAV5, MSHD_CLAMS;  C3PIU4, MSHD_CORA7;  
Q6NFH9, MSHD_CORDI;  Q8FMN5, MSHD_COREF;  A4QGX4, MSHD_CORGB;  
Q8NMJ7, MSHD_CORGL;  Q4JXC9, MSHD_CORJK;  C4LH71, MSHD_CORK4;  
B1VII5, MSHD_CORU7;  Q0RS64, MSHD_FRAAA;  Q2JFW4, MSHD_FRACC;  
A8LDL3, MSHD_FRASN;  D2S4P5, MSHD_GEOOG;  D0L3V5, MSHD_GORB4;  
C7R1N6, MSHD_JONDD;  A6W6C7, MSHD_KINRD;  B2GI63, MSHD_KOCRD;  
D2Q187, MSHD_KRIFD;  C7NK43, MSHD_KYTSD;  C5CC88, MSHD_MICLC;  
A0QAU8, MSHD_MYCA1;  B1MI19, MSHD_MYCA9;  Q7U173, MSHD_MYCBO;  
A1KGV2, MSHD_MYCBP;  C1ALF4, MSHD_MYCBT;  A4T7H0, MSHD_MYCGI;  
B8ZSU0, MSHD_MYCLB;  Q9CBC9, MSHD_MYCLE;  B2HH13, MSHD_MYCMM;  
Q743D5, MSHD_MYCPA;  A4ZHT6, MSHD_MYCS2;  A3Q695, MSHD_MYCSJ;  
A1ULU4, MSHD_MYCSK;  Q1B3A6, MSHD_MYCSS;  A5U0K8, MSHD_MYCTA;  
A5WKI8, MSHD_MYCTF;  C6DVC4, MSHD_MYCTK;  P9WJM6, MSHD_MYCTO;  
P9WJM7, MSHD_MYCTU;  A0PLC7, MSHD_MYCUA;  A1TFB7, MSHD_MYCVP;  
C8XA55, MSHD_NAKMY;  D7AWZ7, MSHD_NOCDD;  Q5Z297, MSHD_NOCFA;  
A1SPL0, MSHD_NOCSJ;  A1R8Y2, MSHD_PAEAT;  D7GG24, MSHD_PROFC;  
B8HD44, MSHD_PSECP;  A9WNI5, MSHD_RENSM;  C0ZP17, MSHD_RHOE4;  
Q0S740, MSHD_RHOJR;  C1ATC6, MSHD_RHOOB;  D2NRH2, MSHD_ROTMD;  
A4FQD4, MSHD_SACEN;  C7MRC4, MSHD_SACVD;  A8LYQ4, MSHD_SALAI;  
A4X1M6, MSHD_SALTO;  D1BE23, MSHD_SANKS;  D6ZEJ5, MSHD_SEGRD;  
D3Q4A8, MSHD_STANL;  Q82G40, MSHD_STRAW;  D7C376, MSHD_STRBB;  
Q9KZV0, MSHD_STRCO;  B1VS15, MSHD_STRGG;  D2B7W7, MSHD_STRRD;  
C9ZFL1, MSHD_STRSW;  D6Y4C5, MSHD_THEBD;  D1A4F4, MSHD_THECD;  
Q47LA0, MSHD_THEFY;  D5UXA4, MSHD_TSUPD;  D1BV84, MSHD_XYLCX;  

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