To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.3.1.191

Accepted Name
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase.
Alternative Name(s)
UDP-3-O-(3-hydroxymyristoyl)-D-glucosamine N-acyltransferase.
UDP-3-O-acyl-glucosamine N-acyltransferase.
Reaction catalysed
(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-((3R)-hydroxytetradecanoyl)-alpha-D-glucosamine <=> UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + a holo-[acyl-carrier-protein]
Comment(s)
  • The enzyme catalyzes a step of lipid A biosynthesis.
  • LpxD from Escherichia coli prefers (R,S)-3-hydroxymyristoyl-[acyl- carrier protein] over (R,S)-3-hydroxypalmitoyl-[acyl-carrier protein].
  • E.coli lipid A acyltransferases do not have an absolute specificity for 14-carbon hydroxy fatty acids but can transfer fatty acids differing by one carbon unit if the fatty acid substrates are available.
  • When grown on 1% propionic acid, lipid A also contains the odd-chain fatty acids tridecanoic acid, pentadecanoic acid, hydroxytridecanoic acid, and hydroxypentadecanoic acid.
  • Formerly EC 2.3.1.n1.
Cross-references
BRENDA2.3.1.191
EC2PDB2.3.1.191
ExplorEnz2.3.1.191
PRIAM enzyme-specific profiles2.3.1.191
KEGG Ligand Database for Enzyme Nomenclature2.3.1.191
IUBMB Enzyme Nomenclature2.3.1.191
IntEnz2.3.1.191
MEDLINEFind literature relating to 2.3.1.191
MetaCyc2.3.1.191
UniProtKB/Swiss-Prot
Q7VRD6, LPXD_BLOFL;  Q493C2, LPXD_BLOPB;  P65323, LPXD_ECO57;  
Q0TLF4, LPXD_ECOL5;  P65322, LPXD_ECOL6;  P21645, LPXD_ECOLI;  
Q1RG10, LPXD_ECOUT;  Q6D8D3, LPXD_PECAS;  Q7N8N7, LPXD_PHOLL;  
Q57T29, LPXD_SALCH;  Q5PD75, LPXD_SALPA;  P0A1X5, LPXD_SALTI;  
P0A1X4, LPXD_SALTY;  Q325W1, LPXD_SHIBS;  Q32JT0, LPXD_SHIDS;  
P65324, LPXD_SHIFL;  Q3Z5H9, LPXD_SHISS;  Q2NRL7, LPXD_SODGM;  
Q8D2H2, LPXD_WIGBR;  P32203, LPXD_YEREN;  Q1CAM4, LPXD_YERPA;  
P58611, LPXD_YERPE;  Q1CFF7, LPXD_YERPN;  Q667J9, LPXD_YERPS;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-