ENZYME entry: EC 2.3.1.191

Accepted Name
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase.
Alternative Name(s)
UDP-3-O-(3-hydroxymyristoyl)-D-glucosamine N-acyltransferase.
UDP-3-O-acyl-glucosamine N-acyltransferase.
Reaction catalysed
(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-((3R)-hydroxytetradecanoyl)-alpha-D-glucosamine <=> UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + a holo-[acyl-carrier-protein]
Comment(s)
  • The enzyme catalyzes a step of lipid A biosynthesis.
  • LpxD from Escherichia coli prefers (R,S)-3-hydroxymyristoyl-[acyl- carrier protein] over (R,S)-3-hydroxypalmitoyl-[acyl-carrier protein].
  • E.coli lipid A acyltransferases do not have an absolute specificity for 14-carbon hydroxy fatty acids but can transfer fatty acids differing by one carbon unit if the fatty acid substrates are available.
  • When grown on 1% propionic acid, lipid A also contains the odd-chain fatty acids tridecanoic acid, pentadecanoic acid, hydroxytridecanoic acid, and hydroxypentadecanoic acid.
  • Formerly EC 2.3.1.n1.
Cross-references
BRENDA2.3.1.191
EC2PDB2.3.1.191
ExplorEnz2.3.1.191
PRIAM enzyme-specific profiles2.3.1.191
KEGG Ligand Database for Enzyme Nomenclature2.3.1.191
IUBMB Enzyme Nomenclature2.3.1.191
IntEnz2.3.1.191
MEDLINEFind literature relating to 2.3.1.191
MetaCyc2.3.1.191
UniProtKB/Swiss-Prot
Q7VRD6, LPXD_BLOFL;  Q493C2, LPXD_BLOPB;  P65323, LPXD_ECO57;  
Q0TLF4, LPXD_ECOL5;  P65322, LPXD_ECOL6;  P21645, LPXD_ECOLI;  
Q1RG10, LPXD_ECOUT;  Q6D8D3, LPXD_PECAS;  Q7N8N7, LPXD_PHOLL;  
Q57T29, LPXD_SALCH;  Q5PD75, LPXD_SALPA;  P0A1X5, LPXD_SALTI;  
P0A1X4, LPXD_SALTY;  Q325W1, LPXD_SHIBS;  Q32JT0, LPXD_SHIDS;  
P65324, LPXD_SHIFL;  Q3Z5H9, LPXD_SHISS;  Q2NRL7, LPXD_SODGM;  
Q8D2H2, LPXD_WIGBR;  P32203, LPXD_YEREN;  Q1CAM4, LPXD_YERPA;  
P58611, LPXD_YERPE;  Q1CFF7, LPXD_YERPN;  Q667J9, LPXD_YERPS;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-