ENZYME entry: EC 2.3.1.193

Accepted Name
tRNA(Met) cytidine acetyltransferase.
Reaction catalysed
(Elongator tRNA(Met))-cytidine(34) + ATP + acetyl-CoA + H(2)O <=> (elongator tRNA(Met))-N(4)-acetylcytidine(34) + ADP + phosphate + CoA
Comment(s)
  • The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNA(Met).
  • Escherichia coli TmcA strictly discriminates elongator tRNA(Met) from tRNA(Ile), which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem.
  • The enzyme can use GTP in place of ATP for formation of N(4)- acetylcytidine.
Cross-references
BRENDA2.3.1.193
EC2PDB2.3.1.193
ExplorEnz2.3.1.193
PRIAM enzyme-specific profiles2.3.1.193
KEGG Ligand Database for Enzyme Nomenclature2.3.1.193
IUBMB Enzyme Nomenclature2.3.1.193
IntEnz2.3.1.193
MEDLINEFind literature relating to 2.3.1.193
MetaCyc2.3.1.193
UniProtKB/Swiss-Prot
A3N059, TMCA_ACTP2;  Q9YBQ6, TMCA_AERPE;  A8ADB3, TMCA_CITK8;  
P76562, TMCA_ECOLI;  Q7VLN6, TMCA_HAEDU;  P44140, TMCA_HAEIN;  
Q5V5M5, TMCA_HALMA;  D4GW73, TMCA_HALVD;  Q5QY69, TMCA_IDILO;  
Q8TYZ5, TMCA_METKA;  D5C1K8, TMCA_NITHN;  Q6D7Q9, TMCA_PECAS;  
C7BGY4, TMCA_PHOAA;  Q9UZ78, TMCA_PYRAB;  Q8ZN74, TMCA_SALTY;  
Q0T243, TMCA_SHIF8;  C3N792, TMCA_SULIY;  A1RY08, TMCA_THEPD;  
Q9KKJ5, TMCA_VIBCH;  A1JL12, TMCA_YERE8;  D0JFM7, TMCA_YERPD;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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