ENZYME entry: EC 2.3.1.206

Accepted Name
3,5,7-trioxododecanoyl-CoA synthase.
Alternative Name(s)
Olivetol synthase.
Reaction catalysed
3 malonyl-CoA + hexanoyl-CoA <=> 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO(2)
Comment(s)
  • A polyketide synthase catalyzing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.
  • The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalyzed by EC 4.4.1.26.
Cross-references
BRENDA2.3.1.206
EC2PDB2.3.1.206
ExplorEnz2.3.1.206
PRIAM enzyme-specific profiles2.3.1.206
KEGG Ligand Database for Enzyme Nomenclature2.3.1.206
IUBMB Enzyme Nomenclature2.3.1.206
IntEnz2.3.1.206
MEDLINEFind literature relating to 2.3.1.206
MetaCyc2.3.1.206
UniProtKB/Swiss-Prot
B1Q2B6, OLIS_CANSA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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