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ENZYME entry: EC 2.3.1.225

Accepted Name
Protein S-acyltransferase.
Alternative Name(s)
DHHC palmitoyl transferase.
G-protein palmitoyltransferase.
S-protein acyltransferase.
Reaction catalysed
Palmitoyl-CoA + [protein]-L-cysteine <=> [protein]-S-palmitoyl-L-cysteine + CoA
Comment(s)
  • The enzyme catalyzes the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity.
  • Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
Cross-references
BRENDA2.3.1.225
EC2PDB2.3.1.225
ExplorEnz2.3.1.225
PRIAM enzyme-specific profiles2.3.1.225
KEGG Ligand Database for Enzyme Nomenclature2.3.1.225
IUBMB Enzyme Nomenclature2.3.1.225
IntEnz2.3.1.225
MEDLINEFind literature relating to 2.3.1.225
MetaCyc2.3.1.225
UniProtKB/Swiss-Prot
Q755Y0, AKR1_ASHGO;  Q4X251, AKR1_ASPFU;  Q7Z8U2, AKR1_ASPOR;  
Q5AL27, AKR1_CANAL;  Q6FJ70, AKR1_CANGA;  P0CS67, AKR1_CRYNB;  
P0CS66, AKR1_CRYNJ;  Q6BP80, AKR1_DEBHA;  Q5B0V6, AKR1_EMENI;  
Q4I8B6, AKR1_GIBZE;  Q875M2, AKR1_KLULA;  Q875S9, AKR1_LACK1;  
Q9UVH3, AKR1_MORAP;  Q876A6, AKR1_NAUCC;  Q7S3M5, AKR1_NEUCR;  
Q876L5, AKR1_SACU7;  Q09701, AKR1_SCHPO;  Q4P6L3, AKR1_USTMA;  
Q6C520, AKR1_YARLI;  P39010, AKR1_YEAST;  Q876L4, AKR2_SACU7;  
Q12013, AKR2_YEAST;  A2VEY9, APP_DROME;  Q750R7, ERFB_ASHGO;  
Q4WWN2, ERFB_ASPFU;  Q59QL0, ERFB_CANAL;  Q6FSS4, ERFB_CANGA;  
Q6BHT4, ERFB_DEBHA;  Q5B3W7, ERFB_EMENI;  Q4I2M7, ERFB_GIBZE;  
Q6CQB5, ERFB_KLULA;  Q7SFL7, ERFB_NEUCR;  O74384, ERFB_SCHPO;  
Q6C890, ERFB_YARLI;  Q06551, ERFB_YEAST;  Q9VUW9, HIP14_DROME;  
Q75AW7, PFA3_ASHGO;  Q4WZL8, PFA3_ASPFU;  Q5ADN9, PFA3_CANAL;  
Q6FW70, PFA3_CANGA;  Q6BMV2, PFA3_DEBHA;  C8VCL4, PFA3_EMENI;  
Q4IA62, PFA3_GIBZE;  Q6CPU8, PFA3_KLULA;  Q7S7C5, PFA3_NEUCR;  
Q6C4W5, PFA3_YARLI;  P42836, PFA3_YEAST;  Q75CB4, PFA4_ASHGO;  
Q4WC37, PFA4_ASPFU;  Q5AGV7, PFA4_CANAL;  Q6FVE6, PFA4_CANGA;  
P0CS69, PFA4_CRYNB;  J9VJ99, PFA4_CRYNH;  P0CS68, PFA4_CRYNJ;  
Q6BLY8, PFA4_DEBHA;  Q5BD15, PFA4_EMENI;  Q4IMZ7, PFA4_GIBZE;  
Q6CUB5, PFA4_KLULA;  Q7SCY6, PFA4_NEUCR;  Q4PE27, PFA4_USTMA;  
Q6C7Q0, PFA4_YARLI;  Q12006, PFA4_YEAST;  Q75D19, PFA5_ASHGO;  
Q4WUK1, PFA5_ASPFU;  Q59NR8, PFA5_CANAL;  Q6FMP5, PFA5_CANGA;  
Q6BP97, PFA5_DEBHA;  Q5B433, PFA5_EMENI;  Q4I1J3, PFA5_GIBZE;  
Q6CRV3, PFA5_KLULA;  Q9C0W9, PFA5_SCHPO;  Q6C7D1, PFA5_YARLI;  
Q03289, PFA5_YEAST;  Q74ZZ2, SWF1_ASHGO;  Q4WN54, SWF1_ASPFU;  
Q5A861, SWF1_CANAL;  Q6FXC6, SWF1_CANGA;  Q6BP23, SWF1_DEBHA;  
Q5BC23, SWF1_EMENI;  Q6CJC5, SWF1_KLULA;  Q7RWM9, SWF1_NEUCR;  
O60069, SWF1_SCHPO;  Q6CG20, SWF1_YARLI;  Q04629, SWF1_YEAST;  
B8A4F0, ZD16A_DANRE;  A0A0R4IF99, ZD16B_DANRE;  Q9M306, ZDH10_ARATH;  
Q7XA86, ZDH11_ARATH;  Q9H8X9, ZDH11_HUMAN;  Q14AK4, ZDH11_MOUSE;  
B3DN87, ZDH12_ARATH;  Q96GR4, ZDH12_HUMAN;  Q8VC90, ZDH12_MOUSE;  
Q6DGF5, ZDH12_RAT;  Q9M1K5, ZDH13_ARATH;  Q8IUH4, ZDH13_HUMAN;  
Q4R690, ZDH13_MACFA;  Q9CWU2, ZDH13_MOUSE;  Q5NVB9, ZDH13_PONAB;  
Q8VYP5, ZDH14_ARATH;  Q8IZN3, ZDH14_HUMAN;  Q8BQQ1, ZDH14_MOUSE;  
Q5M757, ZDH15_ARATH;  Q96MV8, ZDH15_HUMAN;  Q8BGJ0, ZDH15_MOUSE;  
Q2TGJ4, ZDH15_RAT;  Q5FWL7, ZDH15_XENLA;  Q9M115, ZDH16_ARATH;  
Q58CU4, ZDH16_BOVIN;  Q969W1, ZDH16_HUMAN;  Q4R7E2, ZDH16_MACFA;  
Q9ESG8, ZDH16_MOUSE;  Q8L5Y5, ZDH17_ARATH;  Q8IUH5, ZDH17_HUMAN;  
Q80TN5, ZDH17_MOUSE;  E9PTT0, ZDH17_RAT;  Q94C49, ZDH18_ARATH;  
Q9NUE0, ZDH18_HUMAN;  Q5Y5T2, ZDH18_MOUSE;  Q2TGJ1, ZDH18_RAT;  
Q9SB58, ZDH19_ARATH;  Q8WVZ1, ZDH19_HUMAN;  Q810M5, ZDH19_MOUSE;  
Q500Z2, ZDH20_ARATH;  Q0VC89, ZDH20_BOVIN;  Q5W0Z9, ZDH20_HUMAN;  
Q5Y5T1, ZDH20_MOUSE;  Q5PNZ1, ZDH21_ARATH;  A2VDT6, ZDH21_BOVIN;  
Q8IVQ6, ZDH21_HUMAN;  Q9D270, ZDH21_MOUSE;  Q5RB84, ZDH21_PONAB;  
Q52T38, ZDH22_ARATH;  Q8N966, ZDH22_HUMAN;  A0PK84, ZDH22_MOUSE;  
Q2TGI8, ZDH22_RAT;  Q9FLM3, ZDH23_ARATH;  Q8IYP9, ZDH23_HUMAN;  
Q5Y5T3, ZDH23_MOUSE;  Q76IC6, ZDH23_RAT;  Q8VYS8, ZDH24_ARATH;  
Q6UX98, ZDH24_HUMAN;  Q6IR37, ZDH24_MOUSE;  Q2TGI5, ZDH24_RAT;  
Q9C533, ZDHC1_ARATH;  Q550R7, ZDHC1_DICDI;  Q8WTX9, ZDHC1_HUMAN;  
Q8R0N9, ZDHC1_MOUSE;  Q3EC11, ZDHC2_ARATH;  Q86A83, ZDHC2_DICDI;  
Q9UIJ5, ZDHC2_HUMAN;  P59267, ZDHC2_MOUSE;  Q9JKR5, ZDHC2_RAT;  
Q6DR03, ZDHC3_ARATH;  Q557H5, ZDHC3_DICDI;  Q9NYG2, ZDHC3_HUMAN;  
Q8R173, ZDHC3_MOUSE;  O80685, ZDHC4_ARATH;  Q58DT3, ZDHC4_BOVIN;  
Q555N7, ZDHC4_DICDI;  Q9NPG8, ZDHC4_HUMAN;  Q9D6H5, ZDHC4_MOUSE;  
Q5FVR1, ZDHC4_RAT;  Q3EBC2, ZDHC5_ARATH;  E1BLT8, ZDHC5_BOVIN;  
Q2THW9, ZDHC5_CANLF;  Q554E7, ZDHC5_DICDI;  Q9C0B5, ZDHC5_HUMAN;  
Q8VDZ4, ZDHC5_MOUSE;  Q2THX1, ZDHC5_PANTR;  Q5R838, ZDHC5_PONAB;  
Q2THW7, ZDHC5_RAT;  Q93VV0, ZDHC6_ARATH;  Q2HJ95, ZDHC6_BOVIN;  
Q8T2Q0, ZDHC6_DICDI;  Q9H6R6, ZDHC6_HUMAN;  Q9CPV7, ZDHC6_MOUSE;  
Q5REH2, ZDHC6_PONAB;  Q9LIH7, ZDHC7_ARATH;  Q552M6, ZDHC7_DICDI;  
Q9NXF8, ZDHC7_HUMAN;  Q91WU6, ZDHC7_MOUSE;  Q923G5, ZDHC7_RAT;  
Q9LIE4, ZDHC8_ARATH;  Q2THW8, ZDHC8_CANLF;  Q54VH7, ZDHC8_DICDI;  
Q9ULC8, ZDHC8_HUMAN;  Q5Y5T5, ZDHC8_MOUSE;  Q2THX0, ZDHC8_PANTR;  
Q0WQK2, ZDHC9_ARATH;  Q58DA8, ZDHC9_BOVIN;  Q9Y397, ZDHC9_HUMAN;  
P59268, ZDHC9_MOUSE;  Q5R5J8, ZDHC9_PONAB;  Q5FC64, ZDHCS_CAEEL;  
P0C7U3, ZH11B_HUMAN;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-